Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.
Abdurrahman G, Samukange W, Lyoko N, Shonhiwa NO, Kafere C, Nübling CM, Peeling RW, Reinhardt J (2023): Regulation of blood-screening in vitro diagnostics in sub-Saharan African countries remains a challenge.
Front Med Sec Hematology Oct 3 [Epub ahead of print].
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Amberger M, Grueso E, Ivics Z (2023): CRISISS: A Novel, Transcriptionally and Post-Translationally Inducible CRISPR/Cas9-Based Cellular Suicide Switch.
Int J Mol Sci 24: 9799.
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Ammar D, Schapitz I, Luu M, Hudecek M, Meyer M, Taps T, Schröder B, Ivics Z, Sanges C, Franz P, Koehl U, Negre H, Inez J, Awigena-Cook J (2023): Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations.
Front Immunol Nov 24 [Epub ahead of print].
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Arroyo M, Cardoso CM, Hastert FD (2023): In situ Quantification of Cytosine Modification Levels in Heterochromatic Domains of Cultured Mammalian Cells.
Bio Protoc 13: e4716.
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Baker E, Ponder J, Oberdorfer J, Spreitzer I, Bolden J, Marius M, Bonnevay T, Sullivan K (2023): Barriers to the Use of Recombinant Bacterial Endotoxins Test Methods in Parenteral Drug, Vaccine and Device Safety Testing.
Altern Lab Anim 51: 401-410.
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Bartel D, Bonertz A, Hartenstein D, Kaul S, Lauer I, Reeb C, Rösner-Friese K, Sliva K, Zimmer J, Vieths S, Mahler V (2023): Allergen-specific immunotherapy and evidence: A European regulatory perspective.
Allergol Select 12: 198-210.
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Barth I, Weißer K, Gaston-Tischberger D, Mahler V, Keller-Stanislawski B (2023): Anaphylactic reactions after COVID-19 vaccination in Germany.
Allergol Select 7: 90-100.
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Braun AH, Frank AM, Ho N, Buchholz CJ (2023): Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors.
Mol Ther Methods Clin Dev 28: 90-98.
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Dramburg S, Hilger C, Santos AF, de Las Vecillas L, Aalberse RC, Acevedo N, Aglas L, Altmann F, Arruda KL, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilo MB, Blank S, Bosshard PP, Breiteneder H, Brough HA, Bublin M, Campbell D, Caraballo L, Caubet JC, Celi G, Chapman MD, Chruszcz M, Custovic A, Czolk R, Davies J, Douladiris N, Eberlein B, Ebisawa M, Ehlers A, Eigenmann P, Gadermaier G, Giovannini M, Gomez F, Grohman R, Guillet C, Hafner C, Hamilton RG, Hauser M, Hawranek T, Hoffmann HJ, Holzhauser T, Iizuka T, Jacquet A, Jakob T, Janssen-Weets B, Jappe U, Jutel M, Kalic T, Kamath S, Kespohl S, Kleine-Tebbe J, Knol E, Knulst A, Konradsen JR, Korošec P, Kuehn A, Lack G, Le TM, Lopata A, Luengo O, Mäkelä M, Marra AM, Mills C, Morisset M, Muraro A, Nowak-Wegrzyn A, Nugraha R, Ollert M, Palosuo K, Pastorello EA, Patil SU, Platts-Mills T, Pomés A, Poncet P, Potapova E, Poulsen LK, Radauer C, Radulovic S, Raulf M, Rougé P, Sastre J, Sato S, Scala E, Schmid JM, Schmid-Grendelmeier P, Schrama D, Sénéchal H, Traidl-Hoffmann C, Valverde-Monge M, van Hage M, van Ree R, Verhoeckx K, Vieths S, Wickman M, Zakzuk J, Matricardi PM, Hoffmann-Sommergruber K (2023): EAACI Molecular Allergology User's Guide 2.0.
Pediatr Allergy Immunol 34: e13854.
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Eggers M, Schwebke I, Blümel J, Brandt F, Fickenscher H, Gebel J, Hübner N, Müller JA, Rabenau HF, Rapp I, Reiche S, Steinmann E, Steinmann J, Zwicker P, Suchomel M (2023): Suitable Disinfectants with Proven Efficacy for Genetically Modified Viruses and Viral Vectors.
Viruses 15: 2179.
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Fiedler SA, Henseler O, Doll M, Hoffelner M, Funk MB (2023): Überwachung der Blutversorgung in Deutschland: Daten auf der Basis der Meldungen nach § 21 TFG und der Daten einer Pilotstudie.
Bulletin zur Arzneimittelsicherheit 14: 7-11.
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Fiedler SA, Henseler O, Hoffelner M, Doll M, Hutschenreuter G, Hoch J, Weinauer F, Humpe A, Funk MB, Hilger A (2023): Monitoring Blood Supply in Germany: A Regulatory Perspective.
Transfus Med Hemother 50: 129-134.
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Fiedler SA, Oberle D, Henseler O, Heiden M, Funk MB (2023): Follow-Up of Plasma Donors after Quarantine Storage: Results of a 5-Year Survey in Germany.
Transfus Med Hemother 50: 26-29.
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Fischer N, Gulich B, Keßler B, Längin M, Fishman JA, Wolf E, Boller K, Tönjes RR, Godehardt AW (2023): PCR and peptide based PCMV detection in pig – development and application of a combined testing procedure differentiating newly from latent infected pigs.
Xenotransplantation 30: e12803.
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Fischer D, Thies F, Awad O, Brat C, Meybohm P, Baer PC, Müller MM, Urbschat A, Maier TJ, Zacharowski K, Roos J (2023): Red Blood Cell-Derived Microparticles Exert No Cancer Promoting Effects on Colorectal Cancer Cells In Vitro.
Int J Mol Sci 23: 9323.
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Flecks M, Fischer N, Krijnse Locker J, Tönjes RR, Godehardt AW (2023): Analysis of PERV-C superinfection resistance using HA-tagged viruses.
Retrovirology Aug 21 [Epub ahead of print].
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Frech M, Dexel F, Burgard M, Seibel Y (2023): Die nationale Begleitgesetzgebung zum Genehmigungsverfahren klinischer Prüfungen mit Humanarzneimitteln im Rahmen der Verordnung (EU) Nr. 536/2014.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 66: 12-20.
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Goretzki A, Lin Y-L, Meier C, Dorn B, Wolfheimer S, Jamin A, Schott M, Wangorsch A, Vieths S, Jakob Th, Scheurer S, Schülke S (2023): Stimulation of naive B cells with a fusion protein consisting of FlaA and Bet v 1 induces regulatory B cells ex vivo.
Allergy 78: 663-681.
Online-Abstract
Goretzki A, Zimmermann J, Rainer H, Lin YJ, Schülke S (2023): Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment - Disease-Specific Findings (Part 1).
Curr Allergy Asthma Rep 23: 29-40.
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Guillen E, Ekman N, Barry S, Weise M, Wolff-Holz E (2023): A Data Driven Approach to Support Tailored Clinical Programs for Biosimilar Monoclonal Antibodies.
Clin Pharmacol Ther 113: 108-123.
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Halilovic M, Marx-Blümel L, Marx C, Buder K, Beck JF, Sonnemann J: Assessment of HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress.
In: Krämer OH (Hrsg.), HDAC/HAT Function Assessment and Inhibitor Development: Methods and Protocols: Humana Press, 2023. S. 253-268, ISBN 978-1-0716-2788-4
(Methods in Molecular Biology 2589)
He C, Liu Y, Schülke S, Nishio S, Guo Y, Rainer H, Krause M, Cheng TJ, Nochi T, Vieths S, Scheurer S, Matsuda T, Toda M (2023): β-1,3-glucan, but not β-1,3/1,6-glucan, exacerbates experimental food allergy, while both increase IgA induction.
Allergy 79: 503-506.
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Hein S, Sabino C, Benz NI, Görgülü E, Maier TJ, Oberle D, Hildt E (2023): The fourth vaccination with a non-SARS-CoV-2 variant adapted vaccine fails to increase the breadth of the humoral immune response.
Sci Rep 13: 10820.
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Heinen N, Khanal R, Westhoven S, Klöhn M, Herrmann ST, Herrmann M, Tuoc T, Ulmke PA, Nguyen HD, Nguyen HP, Steinmann E, Todt D, Brown RJP, Sharma AD, Pfaender S (2023): Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses.
Gut Dec 12 [Epub ahead of print].
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Hendrich JM, Wangorsch A, Rödel K, Jacob T, Mahler V, Wöhrl BM (2023): Allergenicity and IgE Recognition of New Dau c 1 Allergens from Carrot.
Mol Nutr Food Res 67: e2200421.
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Himmelsbach K, Mueller S, Kress J, Fiedler SA, Miskey C, Ivics Z, Patek A, Chudy M (2023): Second hepatitis C virus transmission by blood components since introduction of mandatory NAT screening in Germany.
Transfusion 63: 339-347.
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Hinken L, Rahn A, Aguirre Dávila L, Willenborg H, Daentzer D (2023): Comparison of molding helmet therapy versus natural course in twins with nonsynostotic head deformation.
J Craniomaxillofac Surg 51: 369-374.
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Hirch T, Brander N, Schenk F, Pöllmann SJ, Reichenbach J, Schubert R, Modlich U (2023): Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia.
Sci Rep 13: 19386.
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Hörner C, Fiedler AH, Bodmer BS, Walz L, Scheuplein VA, Hutzler S, Matrosovich MN, von Messling V, Mühlebach MD (2023): A protective measles virus-derived vaccine inducing long-lasting immune responses against influenza A virus H7N9.
NPJ Vaccines 8: 46.
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Khan AS, Mallet L, Blümel J, Cassart JP, Knezevic I, Ng SHS, Wall M, Jakava-Viljanen M, Logvinoff C, Goios A, Neels P (2023): Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals.
Biologicals 83: 101696.
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Kallen EJJ, Revers A, Fernández-Rivas M, Asero R, Ballmer-Weber B, Barreales L, Belohlavkova S, de Blay F, Clausen M, Dubakiene R, Ebisawa M, Fernández-Perez C, Fritsche P, Fukutomi Y, Gislason D, Hoffmann-Sommergruber K, Jedrzejczak-Czechowicz M, Knulst AC, Kowalski ML, Kralimarkova T, Lidholm J, Metzler C, Mills ENC, Papadopoulos NG, Popov TA, Purohit A, Reig I, Seneviratne SL, Sinaniotis A, Takei M, Versteeg SA, Vassilopoulou AE, Vieths S, Welsing PMJ, Zwinderman AH, Le TM, Van Ree R (2023): A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity.
Allergy 78: 2497-2509.
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Kallio MJ, Starokozhko V, Agricola E, Burggraf M, Heß A, Ballensiefen W, Löbker W, Nuevo Y, Pasmooij AMG, Mol PGM, STARS consortium (2023): Translating Academic Drug Discovery Into Clinical Development: A Survey of the Awareness of Regulatory Support and Requirements Among Stakeholders in Europe.
Clin Pharmacol Ther 113: 349-359.
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Kerren V, Jaedtka M, Baars I, Walber B, Philipp MS, Bagola K, Müller AJ, Heine H, van Zandbergen G (2023): Investigating pyroptosis as a mechanism of L. major cell-to-cell spread in the human BLaER1 infection model.
Mol Microbiol 121: 453-469.
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Kovač A, Miskey C, Ivics Z (2023): Sleeping Beauty Transposon Insertions into Nucleolar DNA by an Engineered Transposase Localized in the Nucleolus.
Int J Mol Sci 24: 14978.
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HC Lehmann, Oberle D, Keller-Stanislawski B, Rieck T, Streit R (2023): Rare cases of Guillain-Barré syndrome after COVID-19 vaccination, Germany, December 2020 to August 2021.
Euro Surveill 28: 2200744.
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Lin YJ, Jamin A, Wolfheimer S, Fiedler A, Junker AC, Goretzki A, Scheurer S, Schülke S (2023): A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages.
Front Immunol 14: 1136669.
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Matz B, Blümel J, Schildgen O, Eis-Hübinger AM, Streeck H (2023): Basic research on herpes simplex viruses: are mutants still needed?.
Virus Genes 59: 790–794.
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Mentzer D, Oberle B, Keller-Stanislawski B (2023): Daten zur Pharmakovigilanz von Impfstoffen aus den Jahren 2019 bis 2021.
Bulletin zur Arzneimittelsicherheit 14: 4-14.
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Mentzer D, Keller-Stanislawski B, Seidel F, Rolfs N (2023): Nachbeobachtung und Vergleich von Kindern und Jugendlichen mit COVID-19-Impfstoff-assoziierter Myokarditis im Vergleich zu nicht impfstoffassoziierter Myokarditis im MYKKE-Register.
Bulletin zur Arzneimittelsicherheit 14: 14-17.
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Mentzer D, Oberle B, Streit R, Weisser K, Keller-Stanislawski B (2023): Sicherheitsprofil der COVID-19-Impfstoffe – Sachstand 31.03.2023.
Bulletin zur Arzneimittelsicherheit 14: 12-29.
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Messelhäusser M, Kopp L, Maurer G, Mentzer D (2023): Überwachung der Impfstoffsicherheit unter Nutzung Künstlicher Intelligenz.
Bulletin zur Arzneimittelsicherheit 14: 18-23.
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Milne C, Wagner R, Cano F, Bruysters M, Waeterloos G, Pullirsch D, Wierer M, Mallet L (2023): Independent control of COVID-19 vaccines by EU Official Control Authority Batch Release: challenges, strengths and successes.
NPJ Vaccines Feb 23 [Epub ahead of print].
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Müller S, Meyer B, Funk MB (2023): Hämovigilanzbericht des Paul-Ehrlich-Instituts 2021: Auswertung der Meldungen von schwerwiegenden Reaktionen und Zwischenfällen nach § 63i AMG – Zusammenfassung.
Bulletin zur Arzneimittelsicherheit 14: 4-6.
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Nguyen Q, Hees K, Hofner B (2023): Adaptive platform trials: the impact of common controls on type one error and power.
J Biopharm Stat Nov 21 [Epub ahead of print].
Online-Abstract
Orru' S, Bierbaum S, Enk A, Hengel H, Hoffelner M, Huzly D, Keller-Stanislawski B, Mahler V, Mockenhaupt M, Oberle D (2023): Skin manifestations after immunisation with an adjuvanted recombinant zoster vaccine, Germany, 2020.
Euro Surveill 28: 2300261.
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Orru' S, Oberle D, Heiden M, Müller S, Krut O, Funk MB (2023): Analysis of Transfusion-Transmitted Bacterial Infections according to German Hemovigilance Data (2011–2020).
Transfus Med Hemother 50: 144-153.
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Pennitz P, Goekeri C, Trimpert J, Wyler E, Ebenig A, Weissfuss C, Mühlebach MD, Witzenrath M, Nouailles G (2023): Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.
STAR Protoc 4: 101957.
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Pfaar O, Hamelmann E, Taube C, Wagenmann M, Wedi B, Werfel T, Bartel D, Bonertz A, Hartenstein D, Kaul S, Mahler V, Worm M (2023): DGAKI and PEI in dialogue 2023: Diagnostics and allergen immunotherapy.
Allergol Select 12: 229-235.
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Pfaar O, Becker S, Calabria C, Hartenstein D, Jung J, Zimmer J, Ponda P (2023): Comparison of allergen immunotherapy practice patterns in inhalant allergies in the United States of America and Europe: Similarities and differences 2023.
World Allergy Organ J 16: 100766.
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Puyskens A, Bayram F, Sesver A, Michel J, Krause E, Bourquain D, Filomena A, Esser-Nobis K, Steffanowski C, Nübling CM, Scheiblauer H, Schaade L, Nitsche A (2023): Performance of 20 rapid antigen detection tests to detect SARS-CoV-2 B.1.617.2 (Delta) and B.1.1.529 (Omicron) variants using a clinical specimen panel from January 2022, Berlin, Germany.
Euro Surveill 28: 2200615.
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Ringler E, Ortega Iannazzo S, Herzig J, Weiss LM, Anzaghe M, Miller L, Waibler Z (2023): Complement protein C3a enhances adaptive immune responses towards FVIII products.
Haematologica 108: 1579-1589.
Online-Abstract
Rodrigues Costa M, Fischer N, Gronewald A, Gulich B, Godehardt AW, Tönjes RR (2023): Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLAD/D Inbred Miniature Swine.
J Virol 97: e00062-23.
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Ruhaltinger D (2023): Ausschreibung des Langener Wissenschaftspreises 2023.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 66: 330.
Samukange WT, Kafere C, Heinrich K, Sabblah GT, Siame MM, Chirinda L, Reinhardt J, Hilger A (2023): Strengthening Blood Regulatory Systems to tackle Africa’s unmet needs for blood and blood products.
Transfus Med Hemother 50: 123-128.
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Schäfer L, Allgöwer S, Holzhauser T (2023): Rapid DNA extraction and colorimetric amplicon visualisation speed up LAMP-based detection of soybean allergen in foods.
Eur Food Res Technol 249: 2875–2886.
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Schambach A, Buchholz CJ, Torres-Ruiz R, Cichutek K, Morgan M, Trapani I, Büning H (2023): A new age of precision gene therapy.
Lancet 403: 568-582.
Online-Abstract
Scheurer S, Junker AC, He C, Schülke S, Toda M (2023): The Role of IgA in the Manifestation and Prevention of Allergic Immune Responses.
Curr Allergy Asthma Rep 23: 589-600.
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Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R (2023): Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
mBio 14: e0225223.
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Seitz R, Gürtler L, Vahlensieck U, Hilger A, Schramm W (2023): Too Early to Abandon Convalescent Plasma for Supportive Treatment of COVID-19.
Transufs Med Hemother 50: 1-3.
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Steigerwald H, Krause M, Gonzalez-Menendez I, Quintanilla-Martinez L, Vieths S, Scheurer S, Albrecht M, Blanco-Pérez F (2023): Peach extract induces systemic and local immune responses in an experimental food allergy model.
Sci Rep 13: 1892.
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Stoliaroff-Pepin A, Peine C, Herath T, Lachmann J, Perriat D, Dörre A, Nitsche A, Michel J, Grossegesse M, Hofmann N, Rinner T, Kohl C, Brinkmann A, Meyer T, Dorner BG, Stern D, Treindl F, Hein S, Werel L, Hildt E, Gläser S, Schühlen H, Isner C, Peric A, Ghouzi A, Reichardt A, Janneck M, Lock G, Schaade L, Wichmann O, Harder T (2023): Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022.
Vaccine 41: 290-293.
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Sudhop T, Krafft H (2023): Wie wird die EU-Verordnung zu klinischen Arzneimittelprüfungen ein Jahr nach ihrem Start bewertet?.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 66: 1-2.
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Sudhop T, Riedel C, Krafft H (2023): Grundzüge des neuen Genehmigungsverfahrens für klinische Arzneimittelprüfungen im Rahmen der Verordnung (EU) Nr. 536/2014 und der Zusammenarbeit zwischen den Mitgliedstaaten.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 66: 3-11.
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Theuerkauf SA, Herrera-Carrillo E, John F, Zinser LJ, Molina MA, Riechert V, Thalheimer FB, Börner K, Grimm D, Chlanda P, Berkhout, Buchholz CJ (2023): AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery.
Biomaterials 303: 122399.
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Vogel J, Hoffmann R, Huber M (2023): Internationale Kampagne #MedSafetyWeek ruft zum Melden von Verdachtsfällen von Nebenwirkungen auf.
Bulletin zur Arzneimittelsicherheit 14: 30-34.
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Wenzel A, Schwedinger E, Thomas J, Wolf R (2023): Pharmakovigilanzreport immunologischer Tierarzneimittel: Analyse der Meldungen unerwünschter Ereignisse in Deutschland aus dem Jahr 2022.
DTBl 71: 1129-1138.
Volltext
Wilkinson SM, Gonçalo M, Aerts O, Badulici S, Dickel H, Gallo R, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Hervella M, Isaksson M, Johansen JD, Mahler V, Niklasson B, Pigatto P, Ponyai G, Rustemeyer T, Schuttelar MLA, Spiewak R, Stingeni L, Thyssen JP, Uter W (2023): The European baseline series and recommended additions: 2023.
Contact Dermatitis 88: 87-92.
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Wu Q, Glitscher M, Tonnemacher S, Schollmeier A, Raupach J, Zahn T, Eberle R, Krijnse-Locker J, Basic M, Hildt E (2023): Presence of intact hepatitis B virions in exosomes.
Cell Mol Gastroenterol Hepatol 15: 237-259.
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Zimmer J, Bonertz A, Kaul S, Vieths S (2023): Introduction of general chapters on standard methods for allergen quantification in the European pharmacopoeia.
Allergy 78: 923-927.
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