Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.
Ascione A, Belfiore M, Vesterinen J, Buda M, Holtkamp W, Luciani F (2024): Charge heterogeneity of therapeutic monoclonal antibodies by different cIEF systems: views on the current situation.
MAbs 16: 2313737.
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Bagato O, Balkema-Buschmann A, Todt D, Weber S, Gömer A, Qu B, Miskey C, Ivics Z, Mettenleiter TC, Finke S, Brown RJP, Breithaupt A, Ushakov DS (2024): Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs.
Microbiol Spectr 12: e02469-23.
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Ballmer-Weber BK, Wangorsch A, Bures P, Hanschmann KM, Gadermaier G, Mattsson L, Mills C, van Ree R, Lidholm J, Vieths S (2024): New light on an old syndrome: role of Api g 7 in mugwort 1 pollen related celery allergy.
J Allergy Clin Immunol May 17 [Epub ahead of print].
Online-Abstract
Baylis SA, Chudy M, Blümel J (2024): In Response: Getting the measure of hepatitis A virus (HAV): A better understanding of the RNA content of HAV reference material and blood donations.
Transfusion 64: 416-418.
Behr-Gross ME, Le Tallec D, Sinitskaya N, Milne C, Etscheid M (2024): Determination of procoagulant activity in human normal immunoglobulin preparations for therapeutic use by FXIa chromogenic assay: Evaluation of test kit sensitivity, reference standard performance and product formulation effects on the FXIa assay.
Pharmeur Bio Sci Notes 2024: 27-75.
Online-Abstract
Bender M, Abicht JM, Reichart B, Leuschen M, Wall F, Radan J, Neumann E, Mokelke M, Buttgereit I, Michel S, Ellgass R, Gieseke K, Steen S, Paskevicius A, Denner J, Godehardt AW, Tönjes RR, Hagl C, Ayares D, Wolf E, Schmoeckel M, Brenner P, Müller MB, Längin M (2024): The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation - First Insights.
Biomedicines 12: 1336.
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Bender D, Koulouri A, Wen X, Glitscher M, Schollmeier A, Fernandes da Costa L, Murra RO, Carra GP, Haberger V, Praefcke GJK, Hildt E (2024): Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
PLoS Pathog 20: e1011976.
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Berg P, Heiden M, Müller S, Meyer B, Witzenhausen C, Ruppert-Seipp G, Kehr S, Funk MB (2024): A national surveillance system for continuous monitoring of blood transfusion safety: German haemovigilance data.
Vox Sang Jun 18 [Epub ahead of print].
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Celis P, Farinelli G, Hidalgo-Simon A, Meij P, Tihaya M, Schüssler-Lenz M, Timón M (2024): EMA commentary on the guideline on quality, nonclinical and clinical aspects of medicinal products containing genetically modified cells.
Br J Clin Pharmacol 90: 1203-1212.
Online-Abstract
Corti N, Chiu C, Cox RJ, Demont C, Devaster JM, Engelhardt OG, Gorringe A, Hassan K, Hoefnagel M, Kamerling I, Krut O, Lane C, Liebers R, Luke C, van Molle W, Morel S, Neels P, Roestenberg M, Rubbrecht M, Smits WK, Stoughton D, Talaat K, Vehreschild MJGT, Wildfire A, Meln I, Olesen OF (2024): Regulatory workshop on challenge strain development and GMP manufacture - A stakeholder meeting report.
Biologicals 85: 101746.
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Dewald F, Steger G, Fish I, Torre-Lage I, Hellriegel C, Milz E, Kolb-Bastigkeit A, Heger E, Fries M, Buess M, Marizy N, Michaelis B, Suárez I, Rubio Quintanares GH, Pirkl M, Aigner A, Oberste M, Hellmich M, Wong A, Orduz JC, Fätkenheuer G, Dötsch J, Kossow A, Moench EM, Quade Q, Neumann U, Kaiser R, Schranz M, Klein F (2024): SARS-CoV-2 Test-to-Stay in Daycare.
Pediatrics 153: e2023064668.
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Ehmann F, Kuhn A, Pasmooij AMG, Humphreys A, van Hengel A, Dooley B, Anliker B, Svensson C, Capaldi D, Henshall D, Cooke E, Zhou H, Bastaerts H, Smink J, van Gerven J, Enes L, Nechev L, Hoefnagel M, Driessens M, Wenger M, Blanquie O, Widomski P, Herold R, Thürmer R, Ruiz S, Thirstrup S, Goody S, Zaks T, Cordò V, Aartsma-Rus AM (2024): Report of the European Medicines Agency Conference on RNA-Based Medicines.
Nucleic Acid Ther 34: 4-11.
Online-Abstract
Eisenbrand G, Buettner A, Diel P, Epe B, Först P, Grune T, Haller D, Heinz V, Hellwig M, Humpf HU, Jäger H, Kulling S, Lampen A, Leist M, Mally A, Marko D, Nöthlings U, Röhrdanz E, Spranger J, Steinberg P, Vieths S, Wätjen W, Hengstler JG (2024): Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.
Arch Toxicol Apr 4 [Epub ahead of print].
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Ertl C, Ruf T, Mentzer D, Kong M, Kramer R, von Bergwelt-Baildon M, Subklewe M, Tomsitz D, Ascierto PA, Dummer R, Gogas H, Lebbé C, Long GV, McArthur G, Neilan TG, Ribas A, Robert C, Schadendorf D, Zimmer L, Eigentler T, Grabbe S, Forschner A, Kähler KC, Milani V, Pföhler C, Hassel J, Gutzmer R, Loquai C, Routy B, Furness AJS, Blank C, Wolchok JD, French LE, Hauschild A, Heinzerling L (2024): The side effect registry immuno-oncology (SERIO) - A tool for systematic analysis of immunotherapy-induced side effects.
Eur J Cancer 199: 113505.
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Esser PL, Rubio Quintanares GH, Langhans B, Heger E, Böhm M, Jensen BEO, Esser S, Lübke N, Fätkenheuer G, Lengauer T, Klein F, Oette M, Rockstroh JK, Boesecke C, Di Cristanziano V, Kaiser R, Pirkl M (2024): Torque Teno Virus load is associated with CDC stage and CD4+ cell count in people living with HIV but unrelated to AIDS-defining events and Human Pegivirus load.
J Infect Dis Jan 17 [Epub ahead of print].
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Frericks N, Brown RJP, Reinecke BM, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran FWR, Steinmann E, Pietschmann T (2024): Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes.
J Virol 98: e0192123.
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Glitscher M, Benz NI, Sabino C, Murra R, Hein S, Zahn T, Mhedhbi I, Stefanova D, Bender D, Werner S, Hildt E (2024): Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and 2 via the PI3K-Akt-mTOR axis the endolysosomal system.
Antiviral Res 226: 105891.
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Glitscher M, Spannaus IM, Behr F, Murra RO, Woytinek K, Bender D, Hildt E (2024): The protease domain in HEV pORF1 mediates the replicase's localization to multivesicular bodies and its exosomal release.
Cell Mol Gastroenterol Hepatol 17: 589-605.
Online-Abstract
Haase N, Holtkamp W, Christ S, Heinemann D, Rodnina MV, Rudorf S (2024): Decomposing bulk signals to reveal hidden information in processive enzyme reactions: A case study in mRNA translation.
PLoS Comput Biol 20: e1011918.
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Haid S, Matthaei A, Winkler M, Sake SM, Gunesch AP, Milke V, Köhler NM, Rückert J, Vieyres G, Kühl D, Nguyen TT, Göhl M, Lasswitz L, Zapatero-Belinchón FJ, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown RJP, Brönstrup M, Schulz TF, Pietschmann T (2024): Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.
Antimicrob Agents Chemother 68: e01210-23.
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Hedberg P, Parczewski M, Serwin K, Marchetti G, Bai F, Jensen BEO, Pereira JPV, Drobniewski F, Reschreiter H, Naumovas D, Ceccherini-Silberstein F, Rubio Quintanares GH, Mwau M, Toscano C, König F, Pfeifer N, Zazzi M, Fanti I, Incardona F, Cozzi-Lepri A, Sönnerborg A, Nauclér P (2024): In-hospital mortality during the wild-type, alpha, delta, and omicron SARS-CoV-2 waves: a multinational cohort study in the EuCARE project.
Lancet Reg Health Eur 38: 100855.
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Hendrich JM, Reuter A, Jacob TP, Kara H, Amer S, Rödel K, Wöhrl BM (2024): Allergenicity and structural properties of new Cor a 1 isoallergens from hazel identified in different plant tissues.
Sci Rep 14: 5618.
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Hildt E, Hu J (2024): New facet of CARs: HBV-specific CARs as inhibitors of virus morphogenesis and release.
Gut Jan 24 [Epub ahead of print].
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Jamali A, Ho N, Braun A, Adabi E, Thalheimer FB, Buchholz CJ (2024): Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models.
EMBO Mol Med 16: 784-804.
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Jirmo AC, Albrecht M, Crnkovic S, Alcazar MAA (2024): Editorial: Cellular and systemic interplay of metabolism and inflammation in the pathogenesis of lung diseases.
Front Immunol Jan 17 [Epub ahead of print].
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Jung-Klawitter S, Richter P, Yuan Y, Welzel K, Kube M, Bähr S, Leibner A, Flory E, Opladen T (2024): Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1.
J Inherit Metab Dis 47: 517-532.
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Kohne F, Schwantes A (2024): Proceedings of the 2023 Viral Clearance Symposium, Session 2: Viral Clearance Strategy and Case Studies.
PDA J Pharm Sci Technol 78: 147-156.
Online-Abstract
Lin C, Kuffour EO, Li T, Gertzen GW, Kaiser J, Luedde T, König R, Gohlke H, Münk C (2024): The ISG15-Protease USP18 Is a Pleiotropic Enhancer of HIV-1 Replication.
Viruses 16: 485.
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Lin YJ, Zimmermann J, Schülke S (2024): Novel adjuvants in allergen-specific immunotherapy: where do we stand?.
Front Immunol Feb 23 [Epub ahead of print].
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Liu J, Corroyer-Dulmont S, Pražák V, Khusainov I, Bahrami K, Welsch S, Vasishtan D, Obarska-Kosińska A, Thorkelsson SR, Grünewald K, Quemin ERJ, Turoňová B, Krijnse Locker J (2024): The palisade layer of the poxvirus core is composed of flexible A10 trimers.
Nat Struct Mol Biol Feb 5 [Epub ahead of print].
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Nguyen QL, Hees K, Hernandez Penna S, König F, Posch M, Bofill Roig M, Meyer EL, Freitag MM, Parke T, Otte M, Dauben HP, Mielke T, Spiertz C, Mesenbrink P, Gidh-Jain M, Pierre S, Morello S, Hofner B (2024): Regulatory Issues of Platform Trials: Learnings from EU-PEARL.
Clin Pharmacol Ther Mar 26 [Epub ahead of print].
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Orru' S, Oberle D, Hoffelner M, Mahler V, Keller-Stanislawski B (2024): Verdachtsfälle von Herpes zoster sowie ausgeprägten Hautreaktionen im Zusammenhang mit der Impfung gegen Herpes zoster und postherpetische Neuralgie: Ergebnisse einer Anwendungsbeobachtung bei mit Shingrix geimpften Personen in Deutschland.
Bulletin zur Arzneimittelsicherheit 15: 16-21.
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Qu B, Miskey C, Gömer A, Kleinert RDV, Calvo Ibanez S, Eberle R, Ebenig A, Postmus D, Nocke MK, Herrmann M, Itotia TK, Herrmann ST, Heinen N, Höck S, Hastert FD, von Rhein C, Schürmann C, Li X, van Zandbergen G, Widera M, Ciesek S, Schnierle BS, Tarr AW, Steinmann E, Goffinet C, Pfaender S, Krijnse Locker J, Mühlebach MD, Todt D, Brown RJP (2024): TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology and drives convergent virus evolution.
Proc Natl Acad Sci U S A 121: e2407437121.
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Rauch E, Amendt T, Lopez Krol A, Lang FB, Linse V, Hohmann M, Keim AC, Kreutzer S, Kawengian K, Buchholz M, Duschner P, Grauer S, Schnierle B, Ruhl A, Burtscher I, Dehnert S, Kuria C, Kupke A, Paul S, Liehr T, Lechner M, Schnare M, Kaufmann A, Huber M, Winkler TH, Bauer S, Yu P (2024): T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms.
Nat Commun 15: 1229.
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Schmoeckel M, Längin M, Reichart B, Abicht JM, Bender M, Michel S, Kamla CE, Denner J, Tönjes RR, Schwinzer R, Marckmann G, Wolf E, Brenner P, Hagl C (2024): Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023.
Thorac Cardiovasc Surg Feb 12 [Epub ahead of print].
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Schollmeier A, Basic M, Glitscher M, Hildt E (2024): The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype.
J Virol Apr 17 [Epub ahead of print].
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Seitz R, Gürtler L, Schramm W (2024): COVID-19: A case for plasma derived natural anticoagulants?.
Biologicals 87: 101781.
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Singh S, Pezeshkpoor B, Jamil MA, Dodt J, Sharma A, Ramar V, Ivaskevicius V, Hethershaw E, Philippou H, Pavlova A, Oldenburg J, Biswas A (2024): Heterozygosity in factor XIII genes and the manifestation of mild inherited factor XIII deficiency.
J Thromb Haemost 22: 379-393.
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Spiric J, Schulenborg T, Holzhauser T, Schuler F, Bonertz A, Lauer I, Bartel D, Vieths S, Mahler V, Reuter A (2024): Quality control of allergen products with mass spectrometry part I: Positioning within the EU regulatory framework.
Allergy Feb 29 [Epub ahead of print].
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Steigerwald H, Blanco-Peréz F, Macías-Camero A, Albrecht M, Huch M, Bender C, Schülke S, Keller J, Krause M, Barbas C, Gonzalez-Menendez I, Quintanilla-Martinez L, Toda M, Barber D, Kulling S, Bunzel M, Vieths S, Villasenor A, Stoll D, Scheurer S (2024): Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice.
Carbohydrate Polymers 334: 122007.
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Strobl MR, Demir H, Wozniak-Knopp G, Wangorsch A, Rüker F, Bohle B (2024): Easy assessment of the avidity of polyclonal allergen-specific serum antibodies.
Clin Exp Allergy 54: 278-285.
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Wangorsch A, Jamin A, Spiric J, Vieths S, Scheurer S, Mahler V, Hofmann SC (2024): Allergic Reaction to a Commercially Available Insect Snack Caused by House Cricket (Acheta domesticus) Tropomyosin.
Mol Nutr Food Res 68: 2300420.
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Weisser K (2024): Toxicokinetics of aluminium - novel insights in an old adjuvan.
Allergo J Int Apr 17 [Epub ahead of print].
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Werner E, Sommer D, Rau H, Kobe B (2024): Licensing Requirements for Avian Vaccines Within the European Union.
Avian Dis 67: 474-479.
Online-Abstract
Zuurveld M, Ogrodowczyk AM, Benedé S, Czolk R, Bavaro SL, Randow S, Markiewicz LH, Wróblewska B, Molina E, Kuehn A, Holzhauser T, Willemsen LEM (2024): Allergenic Shrimp Tropomyosin Distinguishes from a Non-Allergenic Chicken Homolog by Pronounced Intestinal Barrier Disruption and Downstream Th2 Responses in Epithelial and Dendritic Cell (Co)Culture.
Nutrients 16: 1192.
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