Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.
Bender D, Koulouri A, Wen X, Glitscher M, Schollmeier A, Fernandes da Costa L, Murra RO, Carra GP, Haberger V, Praefcke GJK, Hildt E (2024): Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
PLoS Pathog 20: e1011976.
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Glitscher M, Benz NI, Sabino C, Murra R, Hein S, Zahn T, Mhedhbi I, Stefanova D, Bender D, Werner S, Hildt E (2024): Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and 2 via the PI3K-Akt-mTOR axis the endolysosomal system.
Antiviral Res 226: 105891.
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Glitscher M, Spannaus IM, Behr F, Murra RO, Woytinek K, Bender D, Hildt E (2024): The protease domain in HEV pORF1 mediates the replicase's localization to multivesicular bodies and its exosomal release.
Cell Mol Gastroenterol Hepatol 17: 589-605.
Online-Abstract
Hildt E, Hu J (2024): New facet of CARs: HBV-specific CARs as inhibitors of virus morphogenesis and release.
Gut Jan 24 [Epub ahead of print].
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Schollmeier A, Basic M, Glitscher M, Hildt E (2024): The impact of HBx protein on mitochondrial dynamics and associated signaling pathways strongly depends on the hepatitis B virus genotype.
J Virol Apr 17 [Epub ahead of print].
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Schwickert KK, Glitscher M, Bender D, Benz NI, Murra R, Schwickert K, Pfalzgraf S, Schirmeister T, Hellmich UA, Hildt E (2024): Zika virus replication is impaired by a selective agonist of the TRPML2 ion channel.
Antiviral Res 228: 105940.
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Hein S, Sabino C, Benz NI, Görgülü E, Maier TJ, Oberle D, Hildt E (2023): The fourth vaccination with a non-SARS-CoV-2 variant adapted vaccine fails to increase the breadth of the humoral immune response.
Sci Rep 13: 10820.
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Stoliaroff-Pepin A, Peine C, Herath T, Lachmann J, Perriat D, Dörre A, Nitsche A, Michel J, Grossegesse M, Hofmann N, Rinner T, Kohl C, Brinkmann A, Meyer T, Dorner BG, Stern D, Treindl F, Hein S, Werel L, Hildt E, Gläser S, Schühlen H, Isner C, Peric A, Ghouzi A, Reichardt A, Janneck M, Lock G, Schaade L, Wichmann O, Harder T (2023): Effectiveness of vaccines in preventing hospitalization due to COVID-19: A multicenter hospital-based case-control study, Germany, June 2021 to January 2022.
Vaccine 41: 290-293.
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Wu Q, Glitscher M, Tonnemacher S, Schollmeier A, Raupach J, Zahn T, Eberle R, Krijnse-Locker J, Basic M, Hildt E (2023): Presence of intact hepatitis B virions in exosomes.
Cell Mol Gastroenterol Hepatol 15: 237-259.
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Bender D, Glitscher M, Hildt E (2022): Die Virushepatitiden A bis E: Prävalenz, Erregermerkmale und Pathogenese.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65: 139-148.
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Bender D, Hildt E (2022): Back to the Roots: Noncanonical Retrograde Trafficking of the HBV Nucleocapsids.
Cell Mol Gastroenterol Hepatol 15: 797-798.
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Glitscher M, Hildt E, Bender D (2022): Hepatitis B und C: Mechanismen der virusinduzierten Leberpathogenese und Tumorentstehung.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65: 228-237.
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Hein S, Herrlein ML, Mhedhbi I, Bender D, Haberger V, Benz N, Eisert J, Stingl J, Dreher M, Oberle D, Schulze J, Mache C, Budt M, Hildt C, Wolff T, Hildt E (2022): Analysis of BNT162b2- and CVnCoV-elicited sera and of convalescent sera towards SARS-CoV-2 viruses.
Allergy 77: 2080–2089.
Online-Abstract
Hein S, Mhedhbi I, Zahn T, Sabino C, Benz NI, Husria Y, Renelt PM, Braun F, Oberle D, Maier TJ, Hildt C, Hildt E (2022): Quantitative and Qualitative Difference in Antibody Response against Omicron and Ancestral SARS‐CoV‐2 after Third and Fourth Vaccination.
Vaccines (Basel) 10: 796.
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Herrlein ML, Hein S, Zahn T, Mhedhbi I, Raupach J, Husria Y, Benz NI, Eisert J, Bender D, Haberger V, Hastert FD, Henss L, Schnierle BS, Stingl JC, Dreher M, Hildt E (2022): Comparative Investigation of Methods for Analysis of SARS-CoV-2-Spike-Specific Antisera.
Viruses 14: 410.
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Herrlein ML, Schmanke P, Elgner F, Sabino C, Akhras S, Bender D, Glitscher M, Tabari D, Scholl C, Stingl J, Hildt E (2022): Catch Me if You Can: the Crosstalk of Zika Virus and the Restriction Factor Tetherin.
J Virol 96: e0211721.
Online-Abstract
Hildt E (2022): Virale Hepatitis – ein versteckter Killer.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65: 137-138.
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Hildt E (2022): Übersicht über die in der EU zugelassenen COVID-19-Impfstoffe – von der Technologie über die klinische Prüfung zur Zulassung.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65: 1237–1243.
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Hildt E, Schaade L (2022): Impfungen als Instrument der Pandemiebewältigung.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65: 1235-1236.
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Huber S, Braun NJ, Schmacke LC, Quek JP, Murra R, Bender D, Hildt E, Luo D, Heine A, Steinmetzer T (2022): Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J Med Chem 65: 6555-6572.
Online-Abstract
Sediri-Schön H, Lange J, Grabski E, Wagner R, Hildt E (2022): Chargenprüfung als wesentliche Säule der Versorgung mit sicheren und wirksamen Impfstoffen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 65: 1244-1250.
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Wagner R, Meißner J, Grabski E, Sun Y, Vieths S, Hildt E (2022): Regulatory concepts to guide and promote the accelerated but safe clinical development and licensure of COVID-19 vaccines in Europe.
Allergy 77: 72-82.
Online-Abstract
Zahn T, Mhedhbi I, Hein S, Raupach J, Miskey C, Husria Y, Bayanga K, Bartel D, Vieths S, Ivics Z, Oberle D, Keller-Stanislawski K, Herrlein ML, Maier TJ, Hildt E (2022): Persistence of infectious SARS-CoV-2 particles for up to 37 days in patients with mild COVID-19.
Allergy 77: 2053-2066.
Online-Abstract
Basic M, Kubesch A, Kuhnhenn L, Görgülü E, Finkelmeier F, Dietz J, Knabe M, Mücke VT, Mücke MM, Berger A, Zeuzem S, Sarrazin C, Hildt E, Peiffer KH (2021): Not uncommon: HBV genotype G co-infections among healthy European HBV carriers with genotype A and E infection.
Liver Int 41: 1278-1289.
Online-Abstract
Glitscher M, Martín DH, Woytinek K, Schmidt B, Tabari D, Scholl C, Stingl JC, Seelow E, Choi M, Hildt E (2021): Targeting cholesterol metabolism as efficient antiviral strategy against the Hepatitis E virus.
Cell Mol Gastroenterol Hepatol 12: 159-180.
Online-Abstract
Glitscher M, Hildt E (2021): Hepatitis E virus egress and beyond - the manifold roles of the viral ORF3 protein.
Cell Microbiol 23: e13379.
Online-Abstract
Glitscher M, Hildt E (2021): Endosomal Cholesterol in Viral Infections - A Common Denominator?.
Front Physiol 12: 750544.
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Glitscher M, Himmelsbach K, Woytinek K, Schollmeier A, Johne R, Praefcke GJK, Hildt E (2021): Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus.
J Virol 95: e01564-20.
Online-Abstract
Hein S, Benz NI, Eisert J, Herrlein ML, Oberle D, Dreher M, Stingl JC, Hildt C, Hildt E (2021): Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes.
Vaccines (Basel) 9: 1419.
Online-Abstract
Kaiser LM, Harms M, Sauter D, Rawat VPS, Glitscher M, Hildt E, Tews D, Hunter Z, Münch J, Buske C (2021): Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström’s Macroglobulinemia.
Cancers (Basel) 13: 826.
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Sabino C, Bender D, Herrlein ML, Hildt E (2021): The epidermal growth factor receptor is a relevant host factor in the early stages of Zika virus life cycle in vitro.
J Virol 95: e0119521.
Online-Abstract
Wagner R, Hildt E, Grabski E, Sun Y, Meyer H, Lommel A, Keller-Stanislawski B, Müller-Berghaus J, Cichutek K (2021): Accelerated Development of COVID-19 Vaccines: Technology Platforms, Benefits, and Associated Risks.
Vaccines (Basel) 9: 747.
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Grabski E, Hildt E, Wagner R (2020): Zulassungsverfahren für Humanimpfstoffe in Deutschland und Europa und das Präqualifizierungsprogramm der WHO.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63: 4-15.
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Haberger V, Elgner F, Roos J, Bender D, Hildt E (2020): Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells.
Front Cell Dev Biol 8: 44.
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Ivics Z, Amberger M, Zahn T, Hildt E (2020): Immuntherapien zur Behandlung der chronischen Hepatitis-B-Virusinfektion - eine Übersicht unter besonderer Berücksichtigung von CAR-T-Zellen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63: 1357-1364.
Online-Abstract
Jiang B, Hildt E (2020): Intracellular Trafficking of HBV Particles.
Cells 9: E2023.
Online-Abstract
Jiang B, Wen X, Wu Q, Bender D, Carra G, Basic M, Kubesch A, Peiffer KH, Boller K, Hildt E (2020): The N-Terminus Makes the Difference: Impact of Genotype-Specific Disparities in the N-Terminal Part of The Hepatitis B Virus Large Surface Protein on Morphogenesis of Viral and Subviral Particles.
Cells 9: E1898.
Online-Abstract
Maddaluno L, Urwyler C, Rauschendorfer T, Meyer M, Stefanova D, Spörri R, Wietecha M, Ferrarese L, Stoycheva D, Bender D, Li N, Strittmatter G, Nasirujjaman K, Beer HD, Staeheli P, Hildt E, Oxenius A, Werner S (2020): Antagonism of interferon signaling by fibroblast growth factors promotes viral replication.
EMBO Mol Med 12: e11793.
Online-Abstract
Müller C, Obermann W, Schulte FW, Lange-Grünweller K, Oestereich L, Elgner F, Glitscher M, Hildt E, Singh K, Hans-Guido W, Hartmann RK, Ziebuhr J, Grünweller A (2020): Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (-) and the eIF4A-inhibitor Silvestrol.
Antiviral Res 175: 104706.
Online-Abstract
Peiffer KH, Spengler C, Basic M, Jiang B, Kuhnhenn L, Obermann W, Zahn T, Glitscher M, Loglio A, Facchetti F, Carra G, Kubesch A, Vermehren J, Knop V, Graf C, Dietz J, Finkelmeier F, Hermann E, Trebicka J, Grünweller A, Zeuzem S, Sarrazin C, Lampertico P, Hildt E (2020): Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.
JCI Insight 5: e135833.
Online-Abstract
Tabari D, Scholl C, Steffens M, Weickhardt S, Elgner F, Bender D, Herrlein ML, Sabino C, Semkova V, Peitz M, Till A, Brüstle O, Hildt E, Stingl J (2020): Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures.
Viruses 12: 1219.
Online-Abstract
Vieths S, Hildt E, van Zandbergen G (2020): Immuntherapien - Wo stehen wir?.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63: 1319-1321.
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Zahn T, Akhras S, Spengler C, Murra RO, Holzhauser T, Hildt E (2020): A new approach for therapeutic vaccination against chronic HBV infections.
Vaccine 38: 3105-3120.
Online-Abstract
Akhras S, Herrlein ML, Elgner F, Holzhauser T, Hildt E (2019): ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization.
Viruses 11: 748.
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Basic M, Elgner F, Bender D, Sabino C, Herrlein ML, Roth H, Glitscher M, Fath A, Kerl T, Schmalz HG, Hildt E (2019): A synthetic derivative of houttuynoid B prevents cell entry of Zika virus.
Antiviral Res 172: 104644.
Online-Abstract
Bender D, Hildt E (2019): Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and Pathogenesis.
Int J Mol Sci 20: 4659.
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Hildt E, Ludwig MS, Kuhn J (2019): Impfen neu denken: Ansatzpunkte und Perspektiven einer modernen Impfstrategie.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 62: 383-385.
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Jiang B, Peiffer KH, Hildt E (2019): Editorial: HBV-the naked truth? Authors' reply.
Aliment Pharmacol Ther 50: 964-965.
Online-Abstract
Jiang B, Wu Q, Kuhnhenn L, Akhras S, Spengler C, Boller K, Pfeiffer KH, Hildt E (2019): Formation of semi-enveloped particles as a unique feature of a hepatitis B virus PreS1 deletion mutant.
Aliment Pharmacol Ther 50: 940-954.
Online-Abstract
Millies B, von Hammerstein F, Gellert A, Hammerschmidt S, Barthels F, Göppel U, Immerheiser M, Elgner F, Jung N, Basic M, Kersten C, Kiefer W, Bodem J, Hildt E, Windbergs M, Hellmich UA, Schirmeister T (2019): Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases.
J Med Chem 62: 11359-11382.
Online-Abstract
Sabino C, Basic M, Bender D, Elgner F, Himmelsbach K, Hildt E (2019): Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection.
Viruses 11: 524.
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Wagner R, Hildt E (2019): Zusammensetzung und Wirkmechanismen von Adjuvanzien in zugelassenen viralen Impfstoffen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 62: 462-471.
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Wen X, Sun D, Guo J, Elgner F, Wang M, Hildt E, Cheng A (2019): Multifunctionality of structural proteins in the enterovirus life cycle.
Future Microbiol 14: 1147-1157.
Online-Abstract
Cai C, Koch B, Morikawa K, Suda G, Sakamoto N, Rueschenbaum S, Akhras S, Dietz J, Hildt E, Zeuzem S, Welsch C, Lange CM (2018): Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.
Front Immunol 9: 723.
Online-Abstract
Elgner F, Hildt E, Bender D (2018): Relevance of Rab Proteins for the Life Cycle of Hepatitis C Virus.
Front Cell Dev Biol 6: 166.
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Elgner F, Sabino C, Basic M, Ploen D, Grünweller A, Hildt E (2018): Inhibition of Zika Virus Replication by Silvestrol.
Viruses 10: 149.
Online-Abstract
Glitscher M, Himmelsbach K, Woytinek K, Johne R, Reuter A, Spiric J, Schwaben L, Grünweller A, Hildt E (2018): Inhibition of Hepatitis E Virus Spread by the Natural Compound Silvestrol.
Viruses 10: 301.
Online-Abstract
Himmelsbach K, Bender D, Hildt E (2018): Life cycle and morphogenesis of the hepatitis E virus.
Emerg Microbes Infect 7: 196.
Online-Abstract
Himmelsbach K, Hildt E (2018): Identification of various cell culture models for the study of Zika virus.
World J Virol 7: 10-20.
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Kuhnhenn L, Jiang B, Kubesch A, Zeuzem S, Sarrazin C, Hildt E, Peiffer KH (2018): Editorial: HBsAg serum levels in HBeAg-negative chronic HBV infection-is it a matter of genotype? Authors' reply.
Aliment Pharmacol Ther 48: 103-104.
Kuhnhenn L, Jiang B, Kubesch A, Vermehren J, Knop V, Susser S, Dietz J, Carra G, Finkelmeier F, Grammatikos G, Zeuzem S, Sarrazin C, Hildt E, Peiffer KH (2018): Impact of HBV genotype and mutations on HBV DNA and qHBsAg levels in patients with HBeAg-negative chronic HBV infection.
Aliment Pharmacol Ther 47: 1523-1535.
Online-Abstract
Kuhnhenn L, Jiang B, Kubesch A, Zeuzem S, Sarrazin C, Hildt E, Peiffer KH (2018): Letter: impact of HBV genotypes and PC/BCP mutations on serum HBsAg levels in Chinese HBeAg negative patients-Authors' reply.
Aliment Pharmacol Ther 48: 238-239.
Peiffer KH, Kuhnhenn L, Jiang B, Mondorf A, Vermehren J, Knop V, Susser S, Walter D, Dietz J, Carra G, Finkelmeier F, Zeuzem S, Sarrazin C, Hildt E (2018): Divergent preS Sequences in Virion-Associated Hepatitis B Virus Genomes and Subviral HBV Surface Antigen Particles From HBV e Antigen-Negative Patients.
J Infect Dis 218: 114-123.
Online-Abstract
Akhras S, Toda M, Boller K, Himmelsbach K, Elgner F, Biehl M, Scheurer S, Gratz M, Vieths S, Hildt E (2017): Cell-permeable capsids as universal antigen carrier for the induction of an antigen-specific CD8+ T-cell response.
Sci Rep 7: 9630.
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Hassemer M, Finkernagel M, Peiffer KH, Glebe D, Akhras S, Reuter A, Scheiblauer H, Sommer L, Chudy M, Nübling CM, Hildt E (2017): Comparative characterization of hepatitis B virus surface antigen derived from different hepatitis B virus genotypes.
Virology 502: 1-12.
Online-Abstract
Medvedev R, Hildt E, Ploen D (2017): Look who's talking-the crosstalk between oxidative stress and autophagy supports exosomal-dependent release of HCV particles.
Cell Biol Toxicol 33: 211-231.
Online-Abstract
Medvedev R, Ploen D, Spengler C, Elgner F, Ren H, Bunten S, Hildt E (2017): HCV-induced oxidative stress by inhibition of Nrf2 triggers autophagy and favors release of viral particles.
Free Radic Biol Med 110: 300-315.
Online-Abstract
Ren H, Elgner F, Himmelsbach K, Akhras S, Jiang B, Medvedev R, Ploen D, Hildt E (2017): Identification of syntaxin 4 as an essential factor for the hepatitis C virus life cycle.
Eur J Cell Biol 96: 542-552.
Online-Abstract
Weber C, Berberich E, von Rhein C, Henß L, Hildt E, Schnierle BS (2017): Identification of Functional Determinants in the Chikungunya Virus E2 Protein.
PLOS Negl Trop Dis 11: e0005318.
Online-Abstract
Barthel SR, Medvedev R, Heinrich T, Büchner SM, Kettern N, Hildt E (2016): Hepatitis B virus inhibits insulin receptor signaling and impairs liver regeneration via intracellular retention of the insulin receptor.
Cell Mol Life Sci 73: 4121-4140.
Online-Abstract
Elgner F, Donnerhak C, Ren H, Medvedev R, Schreiber A, Weber L, Heilmann M, Ploen D, Himmelsbach K, Finkernagel M, Klingel K, Hildt E (2016): Characterization of α-taxilin as a novel factor controlling the release of hepatitis C virus.
Biochem J 473: 145-155.
Online-Abstract
Elgner F, Ren H, Medvedev R, Ploen D, Himmelsbach K, Boller K, Hildt E (2016): The Intracellular Cholesterol Transport Inhibitor U18666A Inhibits the Exosome-Dependent Release of Mature Hepatitis C Virus.
J Virol 90: 11181-11196.
Online-Abstract
Medvedev R, Hildt E, Ploen D (2016): Look who's talking-the crosstalk between oxidative stress and autophagy supports exosomal-dependent release of HCV particles.
Cell Biol Toxicol 33: 211-231.
Online-Abstract
Medvedev R, Ploen D, Hildt E (2016): HCV and Oxidative Stress: Implications for HCV Life Cycle and HCV-Associated Pathogenesis.
Oxid Med Cell Longev 2016: Article ID 9012580.
Online-Abstract
Ren H, Elgner F, Jiang B, Himmelsbach K, Medvedev R, Ploen D, Hildt E (2016): The Autophagosomal SNARE Protein Syntaxin 17 Is an Essential Factor for the Hepatitis C Virus Life Cycle.
J Virol 90: 5989-6000.
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Jiang B, Himmelsbach K, Ren H, Boller K, Hildt E (2015): Subviral Hepatitis B Virus Filaments, like Infectious Viral Particles, Are Released via Multivesicular Bodies.
J Virol 90: 3330-3341.
Online-Abstract
Masoudi S, Ploen D, Hildt E (2015): Is there an Association between the H1N1 Influenza Pandemic Vaccination and the Manifestation of Narcolepsy?.
J Vaccines Vaccin 6: 280.
Online-Abstract
Peiffer KH, Akhras S, Himmelsbach K, Hassemer M, Finkernagel M, Carra G, Nuebling M, Chudy M, Niekamp H, Glebe D, Sarrazin C, Zeuzem S, Hildt E (2015): Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level.
J Hepatol 62: 791-798.
Online-Abstract
Ploen D, Hildt E (2015): Hepatitis C virus comes for dinner: How the hepatitis C virus interferes with autophagy.
World J Gastroenterol 21: 8492-8507.
Online-Abstract
Masoudi S, Ploen D, Kunz K, Hildt E (2014): The adjuvant component α-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its implication to the development of narcolepsy.
Vaccine 32: 2980-2988.
Online-Abstract
Dayoub R, Vogel A, Schuett J, Lupke M, Spieker SM, Kettern N, Hildt E, Melter M, Weiss TS (2013): Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration.
Mol Med 19: 237-244.
Online-Abstract
Himmelsbach K, Hildt E (2013): The kinase inhibitor Sorafenib impairs the antiviral effect of interferon α on hepatitis C virus replication.
Eur J Cell Biol 92: 12-20.
Online-Abstract
Hoffmann J, Boehm C, Himmelsbach K, Donnerhak C, Roettger H, Weiss TS, Ploen D, Hildt E (2013): Identification of alpha-taxilin as an essential factor for the life cycle of hepatitis B virus.
J Hepatol 59: 934-941.
Online-Abstract
Holmström F, Pasetto A, Nähr V, Brass A, Kriegs M, Hildt E, Broderick KE, Chen M, Ahlén G, Frelin L (2013): A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice.
J Immunol 190: 1113-1124.
Online-Abstract
Lupberger J, Schaedler S, Peiran A, Hildt E (2013): Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase.
World J Gastroenterol 19: 8000-8010.
Online-Abstract
Ploen D, Hafirassou ML, Himmelsbach K, Schille SA, Biniossek ML, Baumert TF, Schuster C, Hildt E (2013): TIP47 is associated with the hepatitis C virus and its interaction with Rab9 is required for release of viral particles.
Eur J Cell Biol 92: 374-382.
Online-Abstract
Ploen D, Hafirassou ML, Himmelsbach K, Sauter D, Biniossek ML, Weiss TS, Baumert TF, Schuster C, Hildt E (2013): TIP47 plays a crucial role in the life cycle of hepatitis C virus.
J Hepatol 58: 1081-1088.
Online-Abstract
Rau SJ, Hildt E, Himmelsbach K, Thimme R, Wakita T, Blum HE, Fischer R (2013): CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c-jun N terminal kinase activation independent from the interferon pathway.
Hepatology 57: 23-36.
Online-Abstract
Mariyanna L, Priyadarshini P, Hofmann-Sieber H, Krepstakies M, Walz N, Grundhoff A, Buchholz F, Hildt E, Hauber J (2012): Excision of HIV-1 proviral DNA by recombinant cell permeable tre-recombinase.
PLoS One 7: e31576.
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Carvajal-Yepes M, Himmelsbach K, Schaedler S, Ploen D, Krause J, Ludwig L, Weiss T, Klingel K, Hildt E (2011): Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small Maf proteins.
J Biol Chem Jan 7 [Epub ahead of print].
Online-Abstract
Benga W, Krieger S, Dimitrova M, Zeisel M, Parnot M, Hildt E, Luo G, MacLauchlan J, Baumert TF, Schuster C (2010): Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.
Hepatology 51: 43-53.
Online-Abstract
Schaedler S, Krause J, Himmelsbach K, Carvajal-Yepes M, Lieder F, Klingel K, Nassal M, Weiss TS, Werner S, Hildt E (2010): Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2.
J Biol Chem 285: 41074-41086.
Online-Abstract
Himmelsbach K, Sauter D, Baumert T, Ludwig L, Blum H, Hildt E (2009): New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication.
Gut 58: 1644-1653.
Online-Abstract
Kriegs M, Bürckstümmer T, Himmelsbach K, Bruns M, Frelin L, Ahlén G, Sällberg M, Hildt E (2009): The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo.
J Biol Chem 284: 28343-28351.
Online-Abstract
Ludwig L, Oswald F, Hoang-Vu C, Dralle H, Hildt E, Schmid RM, Karges W (2009): Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma.
Cancer Lett 275: 194-197.
Online-Abstract
Sauter D, Himmelsbach K, Kriegs M, Carvajal-Yepes M, Hildt E (2009): Localization determines function: N-terminally truncated NS5A fragments accumulate in the nucleus and impair HCV replication.
J Hepatol 50: 861-871.
Online-Abstract
Schädler S, Hildt E (2009): HBV Life Cycle: Entry and Morphogenesis.
Viruses 1: 185-209.
Online-Abstract
Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S (2008): Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.
EMBO J 27: 212-223.
Online-Abstract
Lan L, Gorke S, Rau SJ, Zeisel MB, Hildt E, Himmelsbach K, Carvajal-Yepes M, Huber R, Wakita T, Schmitt-Graeff A, Royer C, Blum HE, Fischer R, Baumert TF (2008): Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner.
J Immunol 181: 4926-4935.
Online-Abstract
Lupberger J, Hildt E (2007): Hepatitis B virus-induced oncogenesis.
World J Gastroenterol 13: 74-81.
Online-Abstract
Bleifuss E, Kammertoens T, Hutloff A, Quarcoo D, Dorner M, Straub P, Uckert W, Hildt E (2006): The translocation motif of hepatitis B virus improves protein vaccination.
Cell Mol Life Sci 63: 627-635.
Online-Abstract
Bürckstümmer, Kriegs M, Lupberger J, Pauli EK, Schmittel S, Hildt E (2006): Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication.
FEBS Lett 580: 575-580.
Online-Abstract
Lupberger J, Mund A, Kock J, Hildt E (2006): Cultivation of HepG2.2.15 on Cytodex-3: higher yield of hepatitis B virus and less subviral particles compared to conventional culture methods.
J Hepatol 45: 547-552.
Online-Abstract
Reifenberg K, Hildt E, Lecher E, Wiese E, Nusser P, Ott S, Yamamura K, Rutter G, Löhler J (2006): IFNgamma expression inhibits LHBs storage disease and ground glass hepatocyte appearance, but exacerbates inflammation and apoptosis in HBV surface protein-accumulating transgenic livers.
Liver Int 26: 986-993.
Online-Abstract
Rüttinger S, Macdonald R, Krämer B, Koberling F, Roos M, Hildt E (2006): Accurate single-pair Förster resonant energy transfer through combination of pulsed interleaved excitation, time correlated single-photon counting, and fluorescence correlation spectroscopy.
J Biomed Opt 11: 024012.
Online-Abstract
Schneider-Brachert W, Tchikov V, Merkel O, Jakob M, Hallas C, Kruse ML, Groitl P, Lehn A, Hildt E, Held-Feindt J, Dobner T, Kabelitz D, Krönke M, Schütze S (2006): Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism.
J Clin Invest 116: 2901-2913.
Online-Abstract
Stoeckl L, Funk A, Kopitzki A, Brandenburg B, Oess S, Will H, Sirma H, Hildt E (2006): Identification of a structural motif crucial for infectivity of hepatitis B viruses.
PNAS 103: 6730-6734.
Online-Abstract
Brandenburg B, Stockl L, Gutzeit C, Roos M, Lupberger J, Schwartlander R, Gelderblom H, Sauer IM, Hofschneider PH, Hildt E (2005): A novel system for efficient gene transfer into primary human hepatocytes via cell-permeable hepatitis B virus-like particle.
Hepatology 42: 1300-1309.
Online-Abstract
Friedrich B, Wollersheim M, Brandenburg B, Foerste R, Will H, Hildt E (2005): Induction of anti-proliferative mechanisms in hepatitis B virus producing cells.
J Hepatol 43: 696-703.
Online-Abstract
Hillemann A, Brandenburg B, Schmidt U, Roos M, Smirnow I, Lemken ML, Lauer UM, Hildt E (2005): Protein transduction with bacterial cytosine deaminase fused to the TLM intercellular transport motif induces profound chemosensitivity to 5-fluorocytosine in human hepatoma cells.
J Hepatol 43: 442-450.
Online-Abstract
Sauer IM, Schwartlander R, Schmid J, Efimova E, Vondran FW, Kehr D, Pless G, Spinelli A, Brandenburg B, Hildt E, Neuhaus P (2005): The SlideReactor--a simple hollow fiber based bioreactor suitable for light microscopy.
Artif Organs 29: 264-267.
Online-Abstract
Gehrke R, Brauchle M, Reifenberg K, Hildt E, Gruetzner U, Schmitz V, Schlicht HJ, Hofschneider PH, Caselmann WH, Rabe C (2004): Accumulation of 8-hydroxy-2'-deoxyguanosine adducts in HBx recombinant HepG2 cells and HBx transgenic mice.
Digestion 70: 117-126.
Online-Abstract
Engelhard K, Werner C, Eberspächer E, Bachl M, Blobner M, Hildt E, Hutzler P, Kochs E (2003): The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats.
Anesth Analg 96: 524-531.
Online-Abstract
Hafner A, Brandenburg B, Hildt E (2003): Reconstitution of gene expression from a regulatory-protein-deficient hepatitis B virus genome by cell-permeable HBx protein.
EMBOreports 4: 767-773.
Tet
Stöckl L, Berting A, Malkowski B, Foerste R, Hoschneider PH, Hildt E (2003): Integrity of c-Raf-1/MEK signal transduction cascade is essential for hepatitis B virus gene expression.
Oncogene 22: 2604-2610.
Online-Abstract
Hildt E, Munz B, Saher G, Reifenberg K, Hofschneider PH (2002): The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice.
EMBO J 21: 525-535.
Online-Abstract
Munz B, Hildt E, Springer M, Blau H (2002): RIP2, a checkpoint in myogenic differentiation.
Mol Cell Biol 22: 5879-5886.
Online-Abstract
Schuster R, Hildt E, Chang SF, Terradillos O, Pollicino T, Lanford R, Gerlich WH, Will H, Schaefer S (2002): Conserved transactivating and pro-apoptotic functions of hepadnaviral X protein in ortho- and avihepadnaviruses.
Oncogene 21: 6606-6613.
Online-Abstract
Chang SF, Netter HJ, Hildt E, Schuster R, Schaefer S, Hsu YC, Rang A, Will H (2001): Duck hepatitis B virus expresses a regulatory HBx-like protein from a hidden open reading frame.
J Virol 75: 161-170.
Online-Abstract
Hübinger G, Müller E, Scheffrahn I, Schneider C, Hildt E, Singer BB, Sigg I, Graf J, Bergmann L (2001): CD30-mediated cell cycle arrest associated with induced expression of p21(CIP1/WAF1) in the anaplastic large cell lymphoma cell line Karpas 299.
Oncogene 20: 590-598.
Online-Abstract
Oess S, Hildt E (2000): Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens.
Gene Ther 7: 750-758.
Online-Abstract
Hildt E, Oess S (1999): Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I.
J Exp Med 189: 1707-1714.
Online-Abstract
Lian B, Hildt E, Ma X (1999): Studies on expression and purification of hepatitis B virus preS1 polypeptide in E. coli.
Chinese J Microbiol Immunol: 367-375.
Saher G, Hildt E (1999): Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice.
J Biol Chem 274: 27651-27657.
Online-Abstract
Hildt E, Hofschneider PH (1998): The PreS2 activators of the hepatitis B virus: activators of tumour promoter pathways.
Recent Results Cancer Res 154: 315-329.
Online-Abstract
Rothmann K, Schnölzer M, Radziwill G, Hildt E, Moelling K, Schaller H (1998): Host cell-virus cross talk: phosphorylation of a hepatitis B virus envelope protein mediates intracellular signaling.
J Virol 72: 10138-10147.
Online-Abstract
Urban S, Hildt E, Eckerskorn C, Sirma H, Kekulé A, Hofschneider PH (1997): Isolation and molecular characterization of hepatitis B virus X-protein from a baculovirus expression system.
Hepatology 26: 1045-1053.
Online-Abstract
Hildt E, Hofschneider PH, Urban S (1996): The role of hepatitis B virus (HBV) in the development of hepatocellular carcinoma.
Semin Virol 7: 333-347.
Online-Abstract
Hildt E, Saher G, Bruss V, Hofschneider PH (1996): The hepatitis B virus large surface protein (LHBs) is a transcriptional activator.
Virology 225: 235-239.
Online-Abstract
Hildt E, Urban S, Eckerskorn C, Hofschneider PH (1996): Isolation of highly purified, functional carboxy-terminally truncated hepatitis B virus middle surface protein activators from eucaryotic expression systems.
Hepatology 24: 502-507.
Online-Abstract
Weiss L, Hildt E, Hofschneider PH (1996): Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC): new aspects of a well-established drug.
Antiviral Res 32: 43-53.
Online-Abstract
Hildt E, Urban S, Hofschneider PH (1995): Characterization of essential domains for the functionality of the MHBst transcriptional activator and identification of a minimal MHBst activator.
Oncogene 11: 2055-2066.
Online-Abstract
Urban S, Hildt E (1994): Use of Ni-NTA resin for isolation of cellular proteins binding to HBV transactivator proteins HBx and MHBst.
Qiagen News 1: 14-16.
Hildt E, Urban S, Lauer UM, Hofschneider PH, Kekulé A (1993): ER-localization and functional expression of the HBV transactivator MHBst.
Oncogene 8: 3359-3367.
Online-Abstract
Hofschneider PH, Kekulé A, Caselmann W, Hildt E, Lauer U, Luber B: HBV as a pathogenic factor in the development of HCC.
In: Hsueh AJW (Hrsg.), Ovarian cell interactions : genes to physiology ; [proceedings of the Ninth Ovarian Workshop on Ovarian Cell Interactions, Genes to Physiology, held July 9 to 11, 1992, in Chapel Hill, North Carolina]. New York [u.a.]: Springer, 1993. 191-192 ISBN 3-540-94052-9 ; 0-387-94052-9
(Proceedings in the Serono Symposia, USA series)
