Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.
Fischer N, Gulich B, Keßler B, Längin M, Fishman JA, Wolf E, Boller K, Tönjes RR, Godehardt AW (2023): PCR and peptide based PCMV detection in pig – development and application of a combined testing procedure differentiating newly from latent infected pigs.
Xenotransplantation 30: e12803.
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Flecks M, Fischer N, Krijnse Locker J, Tönjes RR, Godehardt AW (2023): Analysis of PERV-C superinfection resistance using HA-tagged viruses.
Retrovirology Aug 21 [Epub ahead of print].
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Rodrigues Costa M, Fischer N, Gronewald A, Gulich B, Godehardt AW, Tönjes RR (2023): Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLAD/D Inbred Miniature Swine.
J Virol 97: e00062-23.
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Fischer N, Gulich B, Tönjes RR, Godehardt AW (2022): Limited environmental stability of infectious porcine endogenous retrovirus type C; Usage of reverse transcriptase in combination with viral RNA as markers for infectious virus.
Xenotransplantation 29: e12738.
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Reichart B, Cooper DKC, Längin M, Tönjes RR, Pierson III RN, Wolf E (2022): Cardiac xenotransplantation: From concept to clinic.
Cardiovasc Res 118: 3499-3516.
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Godehardt AW, Fischer N, Rauch P, Gulich B, Boller K, Church GM, Tönjes RR (2020): Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15.
Xenotransplantation 27: e12563.
Online-Abstract
Godehardt AW, Ramm R, Gulich B, Tönjes RR, Hilfiker A (2020): Decellularized pig pulmonary heart valves-Depletion of nucleic acids measured by proviral PERV pol.
Xenotransplantation 27: e12565.
Online-Abstract
Godehardt AW, Tönjes RR (2020): Xenotransplantation of Decellularized Pig Heart valves-Regulatory Aspects in Europe.
Xenotransplantation 27: e12609.
Online-Abstract
Reichart B, Längin M, Radan J, Mokelke M, Buttgereit I, Ying J, Fresch AK, Mayr T, Issl L, Buchholz S, Michel S, Ellgass R, Mihalj M, Egerer S, Baehr A, Kessler B, Kemter E, Kurome M, Zakhartchenko V, Steen S, Sjöberg T, Paskevicius A, Krüger L, Fiebig U, Denner J, Godehardt AW, Tönjes RR, Milusev A, Sfriso R, Rieben R, Walz C, Kirchner T, Ayares D, Lampe K, Schönmann U, Hagl C, Wolf E, Klymiuk N, Abicht JM, Brenner P (2020): Pig-to-non-human primate heart transplantation: the final step toward clinical xenotransplantation?.
J Heart Lung Transplant 39: 751-757.
Online-Abstract
Hawthorne WJ, Cowan PJ, Bühler LH, Yi S, Bottino R, Pierson RN, Ahn C, Azimzadeh A, Cozzi E, Gianello P, Lakey JRT, Luo M, Miyagawa S, Mohiuddin MM, Park CG, Schuurman HJ, Scobie L, Sykes M, Tector J, Tönjes RR, Wolf E, Nuñez JR, Wang W (2019): Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation.
Xenotransplantation 26: e12513.
Online-Abstract
Schilling-Leiß D, Frech M, Tönjes RR, Günay-Winter D (2019): Fragen zur Transplantation von humanen Knochenpräparationen und Weichgewebe.
Implantologie 27: 383-385.
Online-Abstract
Denner J, Godehardt AW, Tönjes RR: Infektionsrisiken und mikrobiologische Sicherheit.
In: Jochen Sautermeister (Hrsg.), Tierische Organe in menschlichen Körpern. Biomedizinische, kulturwissenschaftliche, theologische und ethische Zugänge zur Xenotransplantation. Paderborn: mentis, 2018. S. 45-63, ISBN 978-3-95743-011-3
Godehardt AW, Petkov S, Gulich B, Fischer N, Niemann H, Tönjes RR (2018): Comparative gene expression profiling of pig‐derived iPSC‐like cells: Effects of induced pluripotency on expression of porcine endogenous retrovirus (PERV).
Xenotransplantation 25: e12429.
Online-Abstract
Analysis of data
Tönjes RR (2018): Non‐viral pathogens: Identification, relevance, and prevention for xenotransplantation.
Xenotransplantation 25: e12413.
Online-Abstract
Cooper DKC, Cowan P, Fishman JA, Hering BJ, Mohiuddin MM, Pierson RN 3rd, Sachs DH, Schuurman HJ, Dennis JU, Tönjes RR (2017): Miscellaneous.
Xenotransplantation 24: 12365.
Tönjes RR (2017): Assays: Methods for detection of PERV.
Xenotransplantation Nov 28 [Epub ahead of print].
Cozzi E, Tönjes RR, Gianello P, Bühler LH, Rayat GR, Matsumoto S, Park CG, Kwon I, Wang W, O'Connell P, Jessamine S, Elliott RB, Kobayashi T, Hering BJ (2016): First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 1: update on national regulatory frameworks pertinent to clinical islet xenotransplantation.
Xenotransplantation 23: 14-24.
Online-Abstract
Denner J, Tönjes RR, Takeuchi Y, Fishman J, Scobie L (2016): First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Chapter 5: recipient monitoring and response plan for preventing disease transmission.
Xenotransplantation 23: 53-59.
Online-Abstract
Godehardt AW, Rodrigues Costa M, Tönjes RR (2015): Review on porcine endogenous retrovirus detection assays-impact on quality and safety of xenotransplants.
Xenotransplantation 22: 95-101.
Online-Abstract
Godehardt AW, Schilling-Leiß D, Sanzenbacher R, Tönjes RR (2015): Xenogene Zelltherapeutika : Behandlung von Typ 1 Diabetes mittels porciner Pankreasinseln und -inselzellen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 58: 1281-1288.
Online-Abstract
Godehardt AW, Tönjes RR (2015): Transcriptome analysis for comprehensive profiling of quality and safety of pig cells. Symposium on Xenotransplantation.
Xenotransplantation 22: 161.
Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR (2015): Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future.
Horm Metab Res 47: 31-35.
Online-Abstract
Tönjes RR, Godehardt AW (2015): Impact of PERV infection on the pig transcriptome.
Xenotransplantation 22 (Issue Supplement S1): S8-S9.
Tönjes RR, Hergert P: Germany: Regulation of Tissues and Tissue Banking - A Special Case.
In: Phillips GO (Hrsg.), Legal Basis of Global Tissue Banking: A Proactive Clinical Perspective. Singapore: World Scientific Publishing Co. Pte. Ltd., 2015. S. 211-226 ISBN 987-9814663434
Bhat RK, Rudnick W, Antony JM, Maingat F, Ellestad KK, Wheatley BM, Tönjes RR, Power C (2014): Human Endogenous Retrovirus-K(II) Envelope Induction Protects Neurons during HIV/AIDS.
PLoS One 9: e97984.
Online-Abstract
Costa MR, Fischer N, Gulich B, Tönjes RR (2014): Comparison of porcine endogenous retroviruses infectious potential in supernatants of producer cells and in cocultures.
Xenotransplantation 21: 162-173.
Online-Abstract
Godehardt AW, Tönjes RR (2014): Gene expression profiling of porcine cells and tissues by microarray analysis.
Xenotransplantation 21: 187.
Online-Abstract
Schilling-Leiß D, Witt F, Tönjes RR (2014): Bericht zur Meldung nach § 8d Transplantationsgesetz (TPG) für die Jahre 2009 bis 2011.
Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 57: 111-127.
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Denner J, Tönjes RR (2013): Berlin Symposium on Xenotransplantation. July 13, 2012, Robert Koch Institute, Berlin, in association with the 24th International Congress of the Transplantation Society (TTS), July 15-19, 2012 at the ICC in Berlin.
Xenotransplantation 20: 39-64.
Godehardt AW, Tönjes RR (2013): Update on assays for detection of PERVs.
Xenotransplantation 20: 363.
Tönjes RR (2013): Safe Transplantation.
In: Lifeline. Medical research for healthy lives (International Innovations) 1/ 2013: S. 82-83.
Denner J, Tönjes RR (2012): Infection barriers to successful xenotransplantation focusing on porcine endogenous retroviruses.
Clin Microbiol Rev 25: 318-343.
Online-Abstract
Denner J, Tönjes RR (2012): Berlin Symposium on Xenotransplantation, German DFG-Transregio Research Group Xenotransplantation (FOR 535) together with the 14th Minisymposium Xenotransplantation of the German Working Group Xenotransplantation (DAX), June 9-10, 2011, Robert Koch Institute, Berlin.
Xenotransplantation 19: 2-22.
Hergert P, Tönjes RR: Rechtliche Grundlagen. Kap. 1.5. Genehmigung von Gewebezubereitungen nach § 21a AMG / Kap. 1.6. Pflichten nach Erhalt einer Genehmigung nach § 21a AMG.
In: Jerosch J, Katthagen BD, Pruß A (Hrsg.), Knochentransplantation - Knochenbank und klinische Anwendung von Bankknochen. Köln: Deutscher Ärzte-Verlag, 2012. S. 9-12 ISBN 978-3-7691-0623-7
Denner J, Tönjes RR (2011): Berlin Symposium on Xenotransplantation, German DFG-Transregio Research Group Xenotransplantation together with the 13th Minisymposium Xenotransplantation of the German Working Group Xenotransplantation (DAX), June 3-4, 2010, Robert Koch Institute, Berlin.
Xenotransplantation 18: 56-72.
Dörrschuck E, Fischer N, Bravo IB, Hanschmann KM, Kuiper H, Spötter A, Möller R, Cichutek K, Münk C, Tönjes RR (2011): Restriction of Porcine Endogenous Retrovirus by Porcine APOBEC3 Cytidine Deaminases.
J Virol 85: 3842-3857.
Online-Abstract
Kaulitz D, Mihica D, Dorna J, Costa MR, Petersen B, Niemann H, Tönjes RR, Denner J (2011): Development of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs.
J Virol Methods 175: 60-65.
Online-Abstract
Kaulitz D, Mihica D, Plesker R, Geissler A, Tönjes RR, Denner J (2011): Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C.
Arch Virol 156: 707-710.
Online-Abstract
Küttel-Pritzer EE, Tönjes RR (2011): Tierorgane und Gewebezüchtung als Alternativen?.
Aus Politik und Zeitgeschichte (Organspende und Selbstbestimmung; 20-21): 35-40.
Schilling-Leiß D, Bracone F, Selbert M, Reinmann L, Tönjes RR (2011): Bericht zur Meldung nach § 8d Transplantationsgesetz (TPG) für das Jahr 2008.
Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 54: 1116-1125.
Volltext
Denner J, Tönjes RR (2010): Berlin Symposium on Xenotransplantation, German DFG-Transregio Research Group Xenotransplantation together with the 12th Minisymposium Xenotransplantation of the German Working Group Xenotransplantation (DAX), June 4-5, 2009, Robert Koch Institut, Berlin.
Xenotransplantation 17: 94-120.
Gehling U, Tönjes RR, Gerten G (2010): Übertragung einer Amöbeninfektion durch Hornhauttransplantate.
Bulletin zur Arzneimittelsicherheit 1: 7-9.
Text
Meije Y, Tönjes RR, Fishman JA (2010): Retroviral restriction factors and infectious risk in xenotransplantation.
Am J Transplant 10: 1511-1516.
Online-Abstract
Boller K, Schönfeld K, Lischer S, Fischer N, Hoffmann A, Kurth R, Tönjes RR (2008): Human endogenous retrovirus HERV-K 113 is capable of producing intact viral particles.
J Gen Virol 89: 567-572.
Online-Abstract
Denner J, Tönjes RR (2008): International symposium on xenotransplantation.
Xenotransplantation 15: 290-306.
Dörrschuck E, Münk C, Tönjes RR (2008): APOBEC3 proteins and porcine endogenous retroviruses.
Transplant Proc 40: 959-961.
Online-Abstract
Jungmann A, Tönjes RR (2008): Retrotransposition: another obstacle for xenotransplantation?.
Transplant Proc 40: 596-597.
Online-Abstract
Schilling-Leiß D, Godehardt AW, Scherer J, Cichutek K, Tönjes RR (2008): Genehmigungsverfahren für klassische Gewebezubereitungen gemäß § 21a Arzneimittelgesetz (AMG).
Transfus Med Hemother 35: 453-462.
Online-Abstract
Tönjes RR, Scherer J, Cichutek K: Regelungen des Gewebegesetzes für klassische Gewebezubereitungen und Stand der Genehmigungsverfahren gemäß § 21a Arzneimittelgesetz.
Pühler W., Middel C.-D., Hübner M. (Hrsg.), Praxisleitfaden Gewebegesetz Köln: Deutscher Ärzte-Verlag, 2008. 161-175 ISBN 978-3-7691-3377-6
Denner J, Tönjes RR (2007): International symposium on xenotransplantation.
Xenotransplantation 14: 366-373.
Popp SK, Mann DA, Milburn PJ, Gibbs AJ, McCullagh PJ, Wilson JD, Tönjes RR, Simeonovic CJ (2007): Transient transmission of porcine endogenous retrovirus to fetal lambs after pig islet tissue xenotransplantation.
Immunol Cell Biol 85: 238-248.
Online-Abstract
Denner J, Niemann H, Reichart B, Schmoeckel M, Schwinzer R, Tönjes RR (2006): International symposium on xenotransplantation.
Xenotransplantation 13: 576-587.
Denner J, Tönjes RR (2006): Response to editors' letter in Xenotransplantation on manuscripts on porcine endogenous retroviruses.
Xenotransplantation 13: 282-283.
Preuß T, Fischer N, Boller K, Tönjes RR (2006): Isolation and Characterization of an Infectious Replication-Competent Molecular Clone of Ecotropic Porcine Endogenous Retrovirus Class C.
J Virol 80: 10258-10261.
Online-Abstract
Niebert M, Tönjes RR (2005): Evolutionary spread and recombination of porcine endogenous retroviruses in the suiformes.
J Virol 79: 649-654.
Online-Abstract
Tönjes RR (2004): Wird der Mensch mit tierischen Organen leben? Wissen-Agenda 2010.
Die ZEIT 2.
Online-Abstract
Avidan O, Loya S, Tönjes RR, Sevilya Z, Hizi A (2003): Expression and characterization of a recombinant novel reverse transcriptase of a porcine endogenous retrovirus.
Virology 307: 341-357.
Online-Abstract
Fischer N, Krach U, Niebert M, Tönjes RR (2003): Detection of porcine endogenous retrovirus (PERV) using highly specific antisera against Gag and Env.
Virology 311: 222-228.
Online-Abstract
Klein H, Mueller S, Loeschner B, Toenjes RR, Braun G, Mueller EC, Otto A, Montag T (2003): Cloning, sequencing and recombinant expression of the open reading frame encoding a novel member of the Sarcocystis muris (Apicomplexa) microneme lectin family.
Parasitol Res 90: 84-86.
Online-Abstract
Krach K, Badenhoop K, Tönjes RR (2003): The IDDM associated solitary retroviral promoters DQ-LTR3 and DQ-LTR13 have a distinct impact on the expression of selected DQB1 genes in different cell lines in vitro.
Immunogenetics 55: 521-529.
Online-Abstract
Krach U, Fischer N, Scheef G, Czauderna F, Tönjes RR: Xenogene porzine endogene Retroviren: Genetik und Wirtszellspezifität.
In: Grimm H (Hrsg.), Xenotransplantation, Grundlagen - Chancen - Risiken. Stuttgart, New York: Schattauer, 2003. 213-226. ISBN 3-7945-2058-0
Krach K, Pani MA, Seidl C, Van der Auwera BJ, Gorus FK, Tönjes RR, Badenhoop K, Van Autreve J (2003): DQ-LTR13 modifies type I diabetes (IDDM) susceptibility on high risk DQ haplotypes: reply to the comments of Pascual et al.
Diabetologia 46: 870-871.
Online-Abstract
Niebert M, Kurth R, Tönjes RR (2003): Retroviral safety: analyses of phylogeny, prevalence and polymorphisms of porcine endogenous retroviruses.
Ann Transplant 8: 56-64.
Online-Abstract
Niebert M, Tönjes RR: Molecular Cloning and Functional Characterization of Infectious PERV and Development of Diagnostic Tests.
In: Salomon DR, Wilson C (eds.), Xenotransplantation. Heidelberg: Springer, 2003. 217-237.
(Current Topics in Microbiology and Immunology 278)
Niebert M, Tönjes RR (2003): Analyses of prevalence and polymorphisms of six replication-competent and chromosomally assigned porcine endogenous retroviruses in individual pigs and pig subspecies.
Virology 313: 427-434.
Online-Abstract
Tönjes RR, Niebert M (2003): Relative age of proviral porcine endogenous retrovirus sequences in Sus scrofa based on the molecular clock hypothesis.
J Virol 77: 12363-12368.
Online-Abstract
Andersson AC, Venables PJW, Tönjes RR, Scherer J, Eriksson L, Larsson E (2002): Developmental expression of HERV-R (ERV3) and HERV-K in human tissue.
Virology 297: 220-225.
Online-Abstract
Bieda K, Pani MA, van der Auwera B, Seidl C, Tönjes RR, Gorus F, Usadel KH, Badenhoop K (2002): A retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies type I diabetes susceptibility on high risk DQ haplotypes.
Diabetologia 45: 443-447.
Online-Abstract
Niebert M, Rogel-Gaillard C, Chardon P, Tönjes RR (2002): Characterization of chromosomally assigned replication-competent gamma porcine endogenous retroviruses derived from a large white pig and expression in human cells.
J Virol 76: 2714-2720.
Online-Abstract
Niebert M, Scheef G, Tönjes RR (2002): Wieviele funktionale porcine endogene Retroviren (PERV) hat das Schwein?.
Transplantationsmedizin 14: 166-170.
Online-Abstract
Pani MA, Wood JP, Bieda K, Tönjes RR, Usadel KH, Badenhoop K (2002): The variable endogenous retroviral insertion in the human complement C4 gene: a transmission study in type I diabetes mellitus.
Hum Immunol 63: 481-484.
Online-Abstract
Scheef G, Fischer N, Flory E, Schmitt I, Tönjes RR (2002): Transcriptional regulation of porcine endogenous retroviruses released from porcine and infected human cells by heterotrimeric protein complex NF-Y and impact of immunosuppressive drugs.
J Virol 76: 12553-12563.
Online-Abstract
Scheef G, Fischer N, Tönjes RR (2002): Porcine endogene Retroviren (PERV): Die Passagierung von Viren in humanen Zellen führt zur Adaptation der transkriptionellen Aktivität durch Enhancer-Multimerisierung.
Transplantationsmedizin 14: 246-253.
Online-Abstract
Krach U, Fischer N, Czauderna F, Tönjes RR (2001): Comparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells.
J Virol 75: 5465-5472.
Online-Abstract
Scheef G, Fischer N, Krach U, Tönjes RR (2001): The number of a U3 repeat box acting as an enhancer in long terminal repeats of polytropic replication-competent porcine endogenous retroviruses dynamically fluctuates during serial virus passages on human cells.
J Virol 75: 6933-6940.
Online-Abstract
Scheef G, Fischer N, Tönjes RR (2001): Porcine endogenous retroviruses (PERV): Passaging of virions in human cells caused adaptation of transcriptional activity by enhancer multimerization.
Transplant Linc. 3: 15-22.
Tönjes R R: Humanotrope porcine endogene Retroviren: Struktur und Expression. In: Biotechnologische Verfahren und Möglichkeiten in der Medizin.
D Arndt, G Obe, U Kleeberg (Hrsg.), München: Urban & Vogel, 2001. 152-163 ISBN 3-86094-156-9
(RKI-Schrift: Medizin & Wissen 1/01)
Voisset C, Tönjes RR, Breyton P, Mandrand B, Paranhos-Baccalà G (2001): Specific detection of RT activity in culture supernantants of retrovirus-producing cells, using synthetic DNA as competitor in polymerase enhanced reverse transcriptase assay.
J. Virol. Methods 94: 187-193.
Online-Abstract
Czauderna F, Fischer N, Boller K, Kurth R, Tönjes RR (2000): Establishment and Characterization of molecular clones of porcine endogenous retroviruses replicating on human cells.
J Virol 74: 4028-2038.
Online-Abstract
Donner H, Tönjes RR, Bontrop RE, Kurth R, Usadel KH, Badenhoop K (2000): MHC diversity in Caucasians, investigated using highly heterogeneous non-coding sequence motifs at the DQB1 locus including a retroviral long terminal repeat element, and its comparison to nonhuman primate homologues.
Immunogenetics 51: 898-904.
Online-Abstract
Krach U, Fischer N, Czauderna F, Kurth R, Tönjes RR (2000): Generation and testing of a highly specific antiserum directed against porcine endogenous retrovirus nucleocapsid.
Xenotransplantation 7: 221-229.
Online-Abstract
Tönjes RR (2000): Xenotransplantation: Risiken und Chancen.
Aktuelle Nephrologie 3: 17-32.
Tönjes RR, Czauderna F, Fischer N, Krach U, Boller K, Chardon P, Rogel-Gaillard C, Niebert M, Scheef G, Werner A, Kurth R (2000): Molecularly cloned porcine endogenous retroviruses replicate on human cells.
Transplant Proc 32: 1158-1161.
Online-Abstract
Bachmann KD, Hammer C, Haverich A, Knüppel R, Lilie H, Niemann H, Reichart B, Reiter J, Schreiber HL, Sewing KF, Tönjes RR, Ulrichs K, Wollersheim U (1999): Stellungnahme des Wissenschaftlichen Beirats der Bundesärztekammer zur Xenotransplantation.
Deutsches Ärzteblatt 96: A-1920-1926.
Online-Abstract
Badenhoop K, Donner H, Neumann J, Herwig J, Kurth R, Usadel KH, Tönjes RR (1999): IDDM patients neither show humoral reactivities against endogenous retroviral envelope protein nor do they differ in retroviral mRNA expression from healthy relatives or normal individuals.
Diabetes 48: 215-218.
Online-Abstract
Christensen T, Tönjes RR, zur Megede J, Boller K, Møller-Larsen A (1999): Reverse transcriptase activity and particle production in B lymphoblastoid cell lines established from lymphocytes of patients with multiple sclerosis.
AIDS Res Hum Retroviruses 15: 285.
Online-Abstract
Donner H, Tönjes RR, Bontrop RE, Kurth R, Usadel KH, Badenhoop K (1999): Intronic sequence motifs of HLA-DQB1 are shared between humans, apes and old world monkeys, but a retroviral LTR element (DQLTR3) is human specific.
Tissue Antigens 53: 551-558.
Online-Abstract
Donner H, Tönjes RR, Braun J, Van der Auwera B, Siegmund T, Weets I, Herwig J, Kurth R, Usadel KH, Badenhoop K (1999): The presence or absence of a retroviral long terminal repeat influence the genetic risk for type 1 diabetes confered by HLA DQ haplotypes.
J. Clinical Endocrinology and Metabolism 84: 1404-1408.
Online-Abstract
Kurth R, Löwer R, Tönjes RR, Denner J, Löwer J (1999): Ancient DNA in modern perspective: Expression and function of human endogenous retroviruses.
J Hum Virol 2: 187.
Tönjes RR, Czauderna F, Kurth R (1999): Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.
J Virol 73: 9187-9195.
Online-Abstract
Tönjes RR (1999): Xenogene porcine endogene Retroviren: Genanalysen und Replikationsverhalten.
Transplantationsmedizin 3: 208-216.
Online-Abstract
Hauses M, Tönjes RR, Grez M (1998): The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic cell kinase (hck) gene through binding to two adjacent GC-boxes within the HCK promoter-proximal region.
J Biol Chem 273: 31844-31852.
Online-Abstract
Löwer R, Tönjes RR, Boller K, Denner J, Kaiser B, Phelps RC, Löwer J, Kurth R, Badenhoop K, Donner K, Usadsel KH, Miethke T, Lapatschek M, Wagner H (1998): Development of insulin-dependent diabetes mellitus does not depend on specific expression of the human endogenous retrovirus HERV-K.
Cell 95: 11-14.
Online-Abstract
Tönjes RR (1998): Diabetes und Superantigene.
Spektrum der Wissenschaft 2: 28-30.
Boller K, Janssen O, Schuldes H, Tönjes RR, Kurth R (1997): Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.
J Virol 71: 4581-4588.
Online-Abstract
Boller K, Janssen O, Schuldner H, Tönjes RR, Kurth R (1997): Human antibodies to the endogenous retrovirus HTDV/HERV-K: Anti-viral or autoimmune antibodies?.
Immunbiol. 197: 231.
Boller K, Janssen O, Tönjes RR, Kurth R (1997): Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K.
Eur J Cell Biol 72: 109.
Czauderna F, Tönjes RR, Kurth R (1997): Cloning of full-length HERV-K type 2 proviruses.
J. Mol. Med. 75: B225.
Tönjes RR, Boller K, Limbach C, Lugert R, Kurth R (1997): Characterization of human endogenous retrovirus type K virus-like particles generated from recombinant baculoviruses.
Virology 233: 280-291.
Online-Abstract
Tönjes RR, Kurth R (1997): Recombinant systems for propagation of HERV-K particles.
J. Mol. Med. 75: B225-226.
Tönjes RR, Limbach C, Löwer R, Kurth R (1997): Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.
J. Virol. 71: 2747-2756.
Online-Abstract
Tönjes RR, Paul D, Doenecke D (1997): Transgenic mice transcribing the human H1o histone exhibit a normal phenotype.
Eur. J. Biochem. 245: 97-102.
Online-Abstract
Tönjes RR (1997): Transplantation von Organen aus Schweinen - Gefahren durch endogene Retroviren.
Spektrum der Wissenschaft 7: 15-21.
Traub M, Tönjes RR (1997): Quantitative Polymerase-Kettenreaktion.
BioSpektrum 3: 64-66.
Badenhoop K, Tönjes RR, Rau H, Donner H, Rieker W, Braun J, Herwig J, Mytilineos J, Kurth R, Usadel KH (1996): Endogenous retroviral long terminal repeats of the HLA-DQ region are associated with susceptibility to insulin-dependent diabetes mellitus.
Human Immunology 50: 103–110.
Lugert R, König H, Kurth R, Tönjes R (1996): Specific Suppression of False Positive Signals in the Product-Enhanced Reverse Transcriptase Assay.
Biotechniques 20: 210-217.
Online-Abstract
Simpson GR, Patience C, Löwer R, Tönjes RR, Moore H.D, Weiss R.A, Boyd M T (1996): Endogenous D-Type (HERV-K) related sequences are packaged into retroviral particles in the placenta and possess open reading frames for reverse transcriptase.
Virology 222: 451-456.
Online-Abstract
Tönjes R R, Löwer R, Boller K, Denner J, Hasenmaier B, Kirsch H, König H, Korbmacher C, Limbach C, Lugert R, Phelps RC, Scherer J, The-len K, Löwer J, Kurth R (1996): HERV-K: The biologically most active human endogenous retrovirus family.
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 13: 261-267.
Online-Abstract
Löwer R, Tönjes RR, Korbmacher C, Kurth R, Löwer J (1995): Identification of a rev related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K.
J Virol 69: 141-149.
Online-Abstract
Tönjes RR, Löhler J, O´Sullivan JF, Kay GF, Schmidt GH, Dalemans W, Pavirani A, Paul D (1995): Autocrine mitogen IgEGF cooperates with c-myc or with the Hcs locus during hepatocarcinogenesis in transgenic mice..
Oncogene 10: 765-768.
Online-Abstract
Rinchik EM, Tönjes RR, Paul D, Potter MD (1993): Molecular analysis of radiation-induced albino (c)-locus mutations that cause death at preimplantation stages of development.
Genetics 135: 1107-1116.
Online-Abstract
Tönjes RR, Xanthopoulos KG, Darnell JE Jr, Paul D (1992): Transcriptional control in hepatocytes of normal and c14CoS albino deletion mice.
EMBO J 11: 127-133.
Online-Abstract
Tönjes RR, Weith A, Rinchik EM, Winking H, Carnwath JW, Kaliner B, Paul D (1991): Microclones derived from the mouse chromosome 7 D-E bands map within the proximal region of the c14CoS deletion in albino mutant mice.
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Online-Abstract
