Autorinnen und Autoren des Paul-Ehrlich-Instituts sind durch Fettdruck kenntlich gemacht. Wenn Online-Abstracts oder Volltexte zu den Publikationen verfügbar sind, so sind diese verlinkt.
Kerren V, Jaedtka M, Baars I, Walber B, Philipp MS, Bagola K, Müller AJ, Heine H, van Zandbergen G (2023): Investigating pyroptosis as a mechanism of L. major cell-to-cell spread in the human BLaER1 infection model.
Mol Microbiol 121: 453-469.
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Chansard A, Dubrulle N, Poujol de Molliens M, Falanga PB, Stephen T, Hasan M, van Zandbergen G, Aulner N, Shorte SL, David-Watine B, Milieu Intérieur Consortium (2021): Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.
Front Immunol 12: 685768.
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Chansard A, Dubrulle N, Poujol de Molliens M, Falanga PB, Stephen T, Hasan M, van Zandbergen G, Aulner N, Shorte SL, David-Watine B (2021): Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.
Front Immunol 11: 569331.
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Chanyalew M, Abebe M, Endale B, Girma S, Tasew G, Bobosha K, Zewide M, Howe R, van Zandbergen G, Ritter U, Gadisa E, Aseffa A, Laskay T (2021): Enhanced activation of blood neutrophils and monocytes in patients with Ethiopian localized cutaneous leishmaniasis in response to Leishmania aethiopica Neutrophil activation in Ethiopian cutaneous leishmaniasis.
Acta Trop 220: 105967.
Online-Abstract
Chanyalew M, Abebe M, Endale B, Girma S, Tasew G, van Zandbergen G, Ritter U, Gadisa E, Aseffa A, Laskay T (2021): Enhanced production of pro-inflammatory cytokines and chemokines in Ethiopian cutaneous leishmaniasis upon exposure to Leishmania aethiopica.
Cytokine 145: 155289.
Online-Abstract
Gogesch P, Dudek S, van Zandbergen G, Waibler Z, Anzaghe M (2021): The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.
Int J Mol Sci 22: 8947.
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Krause M, Crauwels P, Blanco Pérez F, Globisch M, Wangorsch A, Henle T, Lidholm J, van Zandbergen G, Vieths S, Scheurer S, Toda M (2021): Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms.
Sci Rep 11: 10141.
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Lin YJ, Papp G, Miskey C, Fiedler A, Goretzki S, Wolfheimer S, Crauwels P, Ivics Z, van Zandbergen G, Vieths S, Scheurer S, Schülke S (2021): The flagellin:allergen fusion protein rFlaA:Betv1 induces a MyD88- and MAPK-dependent activation of glucose metabolism in macrophages.
Cells 10: 2614.
Online-Abstract
Rossmann L, Bagola K, Stephen T, Gerards AL, Walber B, Ullrich A, Schülke S, Kamp C, Spreitzer I, Hasan M, David-Watine B, Shorte S, Bastian M, van Zandbergen G (2021): Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response.
Proc Natl Acad Sci U S A 118: e2103651118.
Online-Abstract
Chanyalew M, Abebe M, Endale B, Girma S, Tasew G, van Zandbergen G, Ritter U, Gadisa E, Aseffa A, Laskay T (2020): Enhanced production of pro-inflammatory cytokines and chemokines in Ethiopian cutaneous leishmaniasis upon exposure to Leishmania aethiopica.
Cytokine 18: 155289.
Online-Abstract
Scheer V, Goldammer M, Flindt S, van Zandbergen G, Hinz T (2020): Therapeutische Immunisierungen gegen Tumore und neurodegenerative Erkrankungen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63: 1373-1379.
Online-Abstract
Turonova B, Sikora M, Schürmann C, Hagen WJH, Welsch S, Blanc FEC, Bülow von S, Gecht M, Bagola K, Hörner C, van Zandbergen G, Mosalaganti S, Schwarz A, Covino R, Mühlebach MD, Hummer G, Krijnse Locker J, Beck M (2020): In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges.
Science 370: 203-208.
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Vieths S, Hildt E, van Zandbergen G (2020): Immuntherapien - Wo stehen wir?.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63: 1319-1321.
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Zander H, Müller-Egert S, Zwiewka M, Groß S, van Zandbergen G, Engelbergs J (2020): Checkpointinhibitoren in der Tumortherapie.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 63: 1322-1330.
Online-Abstract
Crauwels P, Bank E, Walber B, Wenzel UA, Agerberth B, Negatue MC, Alemayehu MA, König R, Ritter U, Reiling N, van Zandbergen G (2019): Cathelicidin mediated elimination of Leishmania in human host macrophages.
Front Immunol 10: 2697.
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Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand JR, Simon M, Bär AL, Brochhausen C, Gerlach RG, Tomiuk S, Hammer K, Wagner S, van Zandbergen G, Binger KJ, Müller DN, Kitada K, Clatworthy MR, Kurts C, Titze J, Abdullah Z, Jantsch J (2019): HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Autophagy 15: 1899-1916.
Online-Abstract
Aga E, Mukherjee A, Rane D, More V, Patil T, van Zandbergen G, Solbach W, Dandapat J, Tackenberg H, Ohms M, Sarkar A, Laskay T (2018): Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade.
Cytokine 112: 21-26.
Online-Abstract
Arens K, Filippis C, Kleinfelder H, Goetzee A, Crauwels P, Reichmann G, Waibler Z, Bagola K, van Zandbergen G (2018): Anti-Tumor Necrosis Factor α Therapeutics Differentially Affect Leishmania Infection of Human Macrophages.
Front Immunol 9: Article 1772.
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Schille S, Crauwels P, Bohn R, Bagola K, Walther P, van Zandbergen G (2018): LC3-associated phagocytosis in microbial pathogenesis.
Int J Med Microbiol 308: 228-236.
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Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Jantsch J, Schatz V, Brown GD, Ritter U (2018): Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development.
Front Immunol 9: 263.
Online-Abstract
Dietze-Schwonberg K, Grewe B, Brosch S, Kuharev J, van Zandbergen G, Rammensee HG, Tenzer S, von Stebut E (2017): In silico prediction of Leishmania major-specific CD8+ epitopes.
Exp Dermatol 26: 838-840.
Online-Abstract
Filippis C, Arens K, Noubissi Nzeteu GA, Reichmann G, Waibler Z, Crauwels P, van Zandbergen G (2017): Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner.
Front Immunol 22: 1880.
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Tasew G, Gadisa E, Abera A, Zewude A, Chanyalew M, Aseffa A, Abebe M, Ritter U, van Zandbergen G, Laskay T, Tafess K (2016): In vitro permissiveness of bovine neutrophils and monocyte derived macrophages to Leishmania donovani of Ethiopian isolate.
Parasit Vectors 9: 218.
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Waisman A, Hövelmeyer N, Diefenbach A, Schuppan D, Reddehase MJ, Kleinert H, Kaina B, Grabbe S, Galle PR, Theobald M, Zipp F, Sahin U, Türeci Ö, Kreiter S, Langguth P, Decker H, van Zandbergen G, Schild H (2016): Past, present and future of immunology in Mainz.
Cell Immunol 308: 1-6.
Crauwels P, Bohn R, Thomas M, Gottwalt S, Jäckel F, Krämer S, Bank E, Tenzer S, Walther P, Bastian M, van Zandbergen G (2015): Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell 1 mediated parasite elimination.
Autophagy 11: 285-297.
Online-Abstract
Krämer S, Crauwels P, Bohn R, Razimski C, Szaszak M, Klinger M, Rupp J, van Zandbergen G (2015): AP-1 Transcription Factor Serves as a Molecular Switch between Chlamydia pneumoniae Replication and Persistence.
Infect Immun 83: 2651-2660.
Online-Abstract
Miller L, Weißmüller S, Ringler E, Crauwels P, van Zandbergen G, Seitz R, Waibler Z, ABIRISK consortium (2015): Danger signal-dependent activation of human dendritic cells by plasma-derived factor VIII products.
Thromb Haemost 114: 268-276.
Online-Abstract
Sarkar A, Möller S, Bhattacharyya A, Behnen M, Rupp J, van Zandbergen G, Solbach W, Laskay T (2015): Mechanisms of apoptosis inhibition in Chlamydia pneumoniae-infected neutrophils..
Int J Med Microbiol 305: 493-500.
Online-Abstract
Schmid M, Dufner B, Dürk J, Bedal K, Stricker K, Prokoph LA, Koch C, Wege AK, Zirpel H, van Zandbergen G, Ecker R, Boghiu B, Ritter U (2015): An Emerging Approach for Parallel Quantification of Intracellular Protozoan Parasites and Host Cell Characterization Using TissueFAXS Cytometry.
PLOS ONE 10: e0139866.
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Recke A, Trog LM, Pas HH, Vorobyev A, Abadpour A, Jonkman MF, van Zandbergern G, Kauderer C, Zillikens D, Vidarsson G, Ludwig RJ (2014): Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo.
J Immunol 193: 1600-1608.
Online-Abstract
Neu C, Sedlag A, Bayer C, Förster S, Crauwels P, Niess JH, van Zandbergen G, Frascaroli G, Riedel CU (2013): CD14-Dependent Monocyte Isolation Enhances Phagocytosis of Listeria monocytogenes by Proinflammatory, GM-CSF-Derived Macrophages.
PLoS One 8: e66898.
Online-Abstract
Sagar A, Klemm C, Hartjes L, Mauerer S, van Zandbergen G, Spellerberg B (2013): The β-hemolysin and intracellular survival of Streptococcus agalactiae in human macrophages.
PLoS One 8: e60160.
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Bruns H, Stegelmann F, Fabri M, Döhner K, van Zandbergen G, Wagner M, Skinner M, Modlin RL, Stenger S (2012): Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages.
J Immunol 189: 4069-4078.
Online-Abstract
Wenzel UA, Bank E, Florian C, Förster S, Zimara N, Steinacker J, Klinger M, Reiling N, Ritter U, van Zandbergen G (2012): Leishmania major parasite stage-dependent host cell invasion and immune evasion.
FASEB J 26: 29-39.
Online-Abstract
Aymanns S, Mauerer S, van Zandbergen G, Wolz C, Spellerberg B (2011): High-level fluorescence labeling of gram-positive pathogens.
PLoS One 6: e19822.
Online-Abstract
Barthelmann J, Nietsch J, Blessenohl M, Laskay T, van Zandbergen G, Westermann J, Kalies K (2011): The protective Th1 response in mice is induced in the T-cell zone only three weeks after infection with Leishmania major and not during early T-cell activation.
Med Microbiol Immunol May 6 [Epub ahead of print].
Online-Abstract
Stenger S, van Zandbergen G (2011): Measuring the killing of intracellular pathogens: Leishmania.
Curr Protoc Immunol 93: 14.23.1–14.23.12.
Online-Abstract
Bussmeyer U, Sarkar A, Broszat K, Lüdemann T, Möller S, van Zandbergen G, Bogdan C, Behnen M, Dumler JS, von Loewenich FD, Solbach W, Laskay T (2010): Impairment of gamma interferon signaling in human neutrophils infected with Anaplasma phagocytophilum.
Infect Immun 78: 358-363.
Online-Abstract
Esmann L, Idel C, Sarkar A, Hellberg L, Behnen M, Möller S, van Zandbergen G, Klinger M, Köhl J, Bussmeyer U, Solbach W, Laskay T (2010): Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.
J Immunol 184: 391-400.
Online-Abstract
Fahrer J, Rieger J, van Zandbergen G, Barth H (2010): The C2-streptavidin delivery system promotes the uptake of biotinylated molecules in macrophages and T-leukemia cells.
Biol Chem 391: 1315-1325.
Online-Abstract
Lamerz AC, Damerow S, Kleczka B, Wiese M, van Zandbergen G, Lamerz J, Wenzel A, Hsu FF, Turk J, Beverley SM, Routier FH (2010): Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major.
Glycobiology 20: 872-882.
Online-Abstract
Lüder CG, Campos-Salinas J, Gonzales-Rey E, van Zandbergen G (2010): Impact of protozoan cell death on parasite-host interactions and pathogenesis.
Parasit Vectors 3: 116.
Online-Abstract
Roth A, König P, van Zandbergen G, Klinger M, Hellwig-Bürgel T, Däubener W, Bohlmann MK, Rupp J (2010): Hypoxia abrogates antichlamydial properties of IFN-γ in human fallopian tube cells in vitro and ex vivo.
Proc Natl Acad Sci U S A 107: 19502-19507.
Online-Abstract
van Zandbergen G, Lüder CG, Heussler V, Duszenko M (2010): Programmed cell death in unicellular parasites: a prerequisite for sustained infection?.
Trends Parasitol 26: 477-483.
Online-Abstract
Ritter U, Frischknecht F, van Zandbergen G (2009): Are neutrophils important host cells for Leishmania parasites?.
Trends Parasitol 25: 505-510.
Online-Abstract
Rupp J, Pfleiderer L, Jugert C, Moeller S, Klinger M, Dalhoff K, Solbach W, Stenger S, Laskay T, van Zandbergen G (2009): Chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages.
PLoS One 4: e6020.
Online-Abstract
Wenzel A, van Zandbergen G (2009): Lipoxin A4 receptor dependent leishmania infection.
Autoimmunity 42: 331-333.
Online-Abstract
Laskay T, van Zandbergen G, Solbach W (2008): Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor.
Immunobiology 213: 183-191.
Online-Abstract
Kleczka B, Lamerz AC, van Zandbergen G, Wenzel A, Gerardy-Schahn R, Wiese M, Routier FH (2007): Targeted gene deletion of Leishmania major UDP-galactopyranose mutase leads to attenuated virulence.
J Biol Chem 282: 10498-10505.
Online-Abstract
Rupp J, Gieffers J, Klinger M, van Zandbergen G, Wrase R, Maass M, Solbach W, Deiwick J, Hellwig-Burgel T (2007): Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells.
Cell Microbiol 9: 2181-2191.
Online-Abstract
van Zandbergen G, Solbach W, Laskay T (2007): Apoptosis driven infection.
Autoimmunity 40: 349-352.
Online-Abstract
Wilde I, Lotz S, Engelmann D, Starke A, van Zandbergen G, Solbach W, Laskay T (2007): Direct stimulatory effects of the TLR2/6 ligand bacterial lipopeptide MALP-2 on neutrophil granulocytes.
Med Microbiol Immunol 196: 61-71.
Online-Abstract
van Zandbergen G, Bollinger A, Wenzel A, Kamhawi S, Voll R, Klinger M, Müller A, Hölscher C, Herrmann M, Sacks D, Solbach W, Laskay T (2006): Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum.
Proc Natl Acad Sci U S A 103: 13837-13842.
Online-Abstract
Rupp J, Koch M, van Zandbergen G, Solbach W, Brandt E, Maass M (2005): Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model.
FEMS Microbiol Lett 242: 203-208.
Online-Abstract
Gieffers J, van Zandbergen G, Rupp J, Sayk F, Krüger S, Ehlers S, Solbach W, Maass M (2004): Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature.
Eur Respir J 23: 506-510.
Online-Abstract
Lotz S, Aga E, Wilde I, van Zandbergen G, Hartung T, Solbach W, Laskay T (2004): Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2.
J Leukoc Biol 75: 467-477.
Online-Abstract
Strassburg A, Droemann D, van Zandbergen G, Kothe H, Dalhoff K (2004): Enhanced PMN response in chronic bronchitis and community-acquired pneumonia.
Eur Respir J 24: 772-778.
Online-Abstract
van der Boog PJ, van Kooten C, van Zandbergen G, Klar-Mohamad N, Oortwijn B, Bos NA, van Remoortere A, Hokke CH, de Fijter JW, Daha MR (2004): Injection of recombinant FcalphaRI/CD89 in mice does not induce mesangial IgA deposition.
Nephrol Dial Transplant 19: 2729-2736.
Online-Abstract
van Zandbergen G, Gieffers J, Kothe H, Rupp J, Bollinger A, Aga E, Klinger M, Brade H, Dalhoff K, Maass M, Solbach W, Laskay T (2004): Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis.
J Immunol 172: 1768-1776.
Online-Abstract
van Zandbergen G, Klinger M, Mueller A, Dannenberg S, Gebert A, Solbach W, Laskay T (2004): Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages.
J Immunol 173: 6521-6525.
Online-Abstract
Laskay T, van Zandbergen G, Solbach W (2003): Neutrophil granulocytes--Trojan horses for Leishmania major and other intracellular microbes?.
Trends Microbiol 11: 210-214.
Online-Abstract
Schultz H, Heintz H, van Zandbergen G, Ullrich S, Reinhold-Keller E, Gross WL (2003): ANCA against the bactericidal/permeability increasing protein (BPI-ANCA) can compromise the antibiotic function of BPI in a Wegener's granulomatosis patient.
Clin Exp Rheumatol 21: 763-766.
Online-Abstract
Aga E, Katschinski DM, van Zandbergen G, Laufs H, Hansen B, Müller K, Solbach W, Laskay T (2002): Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major.
J Immunol 169: 898-905.
Online-Abstract
Kreft B, Jabs WJ, Laskay T, Klinger M, Solbach W, Kumar S, van Zandbergen G (2002): Polarized expression of Tamm-Horsfall protein by renal tubular epithelial cells activates human granulocytes.
Infect Immun 70: 2650-2656.
Online-Abstract
van der Boog PJ, van Zandbergen G, de Fijter JW, Klar-Mohamad N, van Seggelen A, Brandtzaeg P, Daha MR, van Kooten C (2002): Fc alpha RI/CD89 circulates in human serum covalently linked to IgA in a polymeric state.
J Immunol 168: 1252-1258.
Online-Abstract
van Zandbergen G, Hermann N, Laufs H, Solbach W, Laskay T (2002): Leishmania promastigotes release a granulocyte chemotactic factor and induce interleukin-8 release but inhibit gamma interferon-inducible protein 10 production by neutrophil granulocytes.
Infect Immun 70: 4177-4184.
Online-Abstract
Müller K, van Zandbergen G, Hansen B, Laufs H, Jahnke N, Solbach W, Laskay T (2001): Chemokines, natural killer cells and granulocytes in the early course of Leishmania major infection in mice.
Med Microbiol Immunol 190: 73-76.
Online-Abstract
van Egmond M, van Garderen E, van Spriel AB, Damen CA, van Amersfoort ES, van Zandbergen G, van Hattum J, Kuiper J, van de Winkel JG (2000): FcalphaRI-positive liver Kupffer cells: reappraisal of the function of immunoglobulin A in immunity.
Nat Med 6: 680-685.
Online-Abstract
Morton HC, van Zandbergen G, van Kooten C, Howard CJ, van de Winkel JG, Brandtzaeg P (1999): Immunoglobulin-binding sites of human FcalphaRI (CD89) and bovine Fcgamma2R are located in their membrane-distal extracellular domains.
J Exp Med 189: 1715-1722.
Online-Abstract
van Zandbergen G, Westerhuis R, Mohamad NK, van De Winkel JG, Daha MR, van Kooten C (1999): Crosslinking of the human Fc receptor for IgA (FcalphaRI/CD89) triggers FcR gamma-chain-dependent shedding of soluble CD89.
J Immunol 163: 5806-5812.
Online-Abstract
Westerhuis R, van Zandbergen G, Verhagen NA, Klar-Mohamad N, Daha MR, van Kooten C (1999): Human mesangial cells in culture and in kidney sections fail to express Fc alpha receptor (CD89).
J Am Soc Nephrol 10: 770-778.
Online-Abstract
van Zandbergen G, van Kooten C, Mohamad NK, Reterink TJ, de Fijter JW, van de Winkel JG, Daha MR (1998): Reduced binding of immunoglobulin A (IgA) from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor, CD89.
Nephrol Dial Transplant 13: 3058-3064.
Online-Abstract
Reterink TJ, van Zandbergen G, van Egmond M, Klar-Mohamad N, Morton CH, van de Winkel JG, Daha MR (1997): Size-dependent effect of IgA on the IgA Fc receptor (CD89).
Eur J Immunol 27: 2219-2224.
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