Paul-Ehrlich-Institut

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Seasonal Influenza 2024/2025

Information on the vaccines approved in Germany, the approved vaccine doses and the vaccine base composition for the 2024/2025 season

Vaccines

The basic composition of the influenza vaccines has to be adapted to the current epidemiological situation every year because the properties of the circulating influenza viruses change. The exact composition is determined each year by the World Health Organization (WHO). This adjustment is checked for each vaccine in a procedure to change the approval. After approval of the strain adaptation, the Paul-Ehrlich-Institut tests and releases the manufactured influenza vaccines in batches, which can then be put on the market and used.

Released Vaccine Doses

Kumulative Anzahl der freigegebenen Dosen Influenza-Impfstoffe in Deutschland / Cumulative number of released doses of influenza vaccines in Germany (Stand/ as of: 24.11.2024 / 24 November 2024) Stand/ as of: 24.11.2024 / 24 November 2024 (Quelle / Source: Paul-Ehrlich-Institut)

DateCalendar-
week
Number of Doses of Vaccines
(total Number)
24 November 202447aprox. 20.0 Million
17 November 202446aprox. 19.9 Million
10 November 202445aprox. 19.9 Million
3 November 202444aprox. 19.9 Million
27 October 202443aprox. 19.9 Million
20 October 202442aprox. 19.9 Million
13 October 202441aprox. 19.8 Million
6 October 202440aprox. 18.7 Million
29 September 202439aprox. 18.7 Million
22 September 202438aprox. 18.1 Million
15 September 202437aprox. 17.6 Million
8 September 202436aprox. 16.9 Million
1 September 202435aprox. 15.5 Million
25 August 202434aprox. 14.2 Million
18 August 202433aprox. 12.1 Million
11 August 202432aprox. 11 Million
4 August 202431aprox. 5.6 Million

Composition of Influenza Virus Vaccines for the 2024/2025 Season

The influenza vaccine for the 2024/2025 season is composed of the antigens of globally circulating variants of viruses according to the recommendations of the WHO and the Committee for Medicinal Products for Human Use (CHMP) at the European Medicines Agency (EMA).

This composition differs from that of the 2023/2024 season.

Composition of Trivalent Vaccines

Egg-based Vaccines

WHO Recommendations* for the northern hemisphereSuitable strains according to the recommendations of the EMA
A/Victoria/4897/2022 (H1N1)pdm09-like virus
  • reassortant virus IVR-238, which is derived from A/Victoria/4897/2022
A/Thailand/8/2022 (H3N2)-like virus
  • reassortant virus IVR-237, which is derived from A/Thailand/8/2022
  • reassortant virus SAN-022, which is derived from A/California/122/2022
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
  • B/Michigan/01/2021 (wild type)
  • reassortant virus BVR-26, which is derived from B/Austria/1359417/2021

Cell-based Vaccines

WHO Recommendations* for the northern hemisphereSuitable strains according to the recommendations of the EMA
A/Wisconsin/67/2022 (H1N1)pdm09-like virus
  • reassortant virus CVR-167, which is derived from A/Georgia/12/2022
A/Massachusetts/18/2022 (H3N2)-like virus
  • A/California/45/2023 (wild type)
B/Austria/1359417/2021 (B/Victoria lineage)-like virus
  • B/Singapore/WUH4618/2021 (wild type)

Live attenuated Vaccines

WHO Recommendations* for the northern hemisphereSuitable strains according to the recommendations of the EMA
A/Victoria/4897/2022 (H1N1)pdm09-like virusVirus MEDI 369815, which is derived from A/Norway/31694/2022
A/Thailand/8/2022 (H3N2)-like virusVirus MEDI 370626, which is derived from A/Thailand/8/2022
B/Austria/1359417/2021 (B/Victoria lineage)-like virusVirus MEDI 355292, which is derived from B/Austria/1359417/2021

Composition of Quadrivalent Vaccines

For the production of inactivated quadrivalent vaccines containing two influenza B virus strains, a B/Phuket/3073/2013 (B/Yamagata lineage)-like strain is considered suitable for the 2024/2025 season in addition to the strains mentioned above.

Egg-based Vaccines

WHO Recommendations* for the northern hemisphereSuitable strains according to the recommendations of the EMA
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
  • B/Phuket/3073/2013 (wild type)
  • reassortant virus BVR-1B, which is derived from B/Phuket/3073/2013

Cell-based Vaccines

WHO Recommendations* for the northern hemisphereSuitable strains according to the recommendations of the EMA
B/Phuket/3073/2013 (B/Yamagata lineage)-like virus
  • B/Singapore/INFTT-16-0610/2016 (wild type)

* A and B denote the virus types, the place name refers to the place of virus isolation; the first digit indicates the number of the isolated strain, the second refers to the year of isolation. H and N are the two most important proteins in the virus envelope hemagglutinin and neuraminidase, the number behind them indicates the hemagglutinin and neuraminidase subtype.

Updated: 15.04.2025