The prompt collection and assessment of suspected post-vaccination adverse events is essential for performing continuous benefit-risk assessments and ensuring vaccine safety. Timely action is especially important in a pandemic situation in which a large number of people are vaccinated in a short period of time. A great deal of information on vaccine use must be collected and evaluated in a short time in the course of a national pandemic vaccination campaign. Efficient action is required. The following article presents several possibilities for the use of artificial intelligence (AI) and continuous digitalisation in the field of vaccine pharmacovigilance.