Please note: Authors from the Paul-Ehrlich-Institut are highlighted in bold. For online abstracts or full text publications, please follow the links.
PubMed - List of publications (Author Dr Richard J.P. Brown)
Frericks N, Brown RJP, Reinecke BM, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran FWR, Steinmann E, Pietschmann T (2024): Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes.
J Virol 98: e0192123.
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Haid S, Matthaei A, Winkler M, Sake SM, Gunesch AP, Milke V, Köhler NM, Rückert J, Vieyres G, Kühl D, Nguyen TT, Göhl M, Lasswitz L, Zapatero-Belinchón FJ, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown RJP, Brönstrup M, Schulz TF, Pietschmann T (2024): Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets.
Antimicrob Agents Chemother 68: e01210-23.
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Qu B, Miskey C, Gömer A, Kleinert RDV, Calvo Ibanez S, Eberle R, Ebenig A, Postmus D, Nocke MK, Herrmann M, Itotia TK, Herrmann ST, Heinen N, Höck S, Hastert FD, von Rhein C, Schürmann C, Li X, van Zandbergen G, Widera M, Ciesek S, Schnierle BS, Tarr AW, Steinmann E, Goffinet C, Pfaender S, Krijnse Locker J, Mühlebach MD, Todt D, Brown RJP (2024): TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology and drives convergent virus evolution.
Proc Natl Acad Sci U S A 121: e2407437121.
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Ebenig A, Muraleedharan S, Kazmierski J, Todt D, Auste A, Anzaghe M, Gömer A, Postmus D, Gogesch P, Niles M, Plesker R, Miskey C, Gellhorn Serra M, Breithaupt A, Hörner C, Kruip C, Ehmann R, Ivics Z, Waibler Z, Pfaender S, Wyler E, Landthaler M, Kupke A, Nouailles G, Goffinet C, Brown RJP, Mühlebach MD (2022): Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization.
Cell Rep 40: 111214.
Online-Abstract
Gömer A, Brown RJP, Pfaender S, Deterding K, Reuter G, Orton R, Seitz S, Bock CT, Cavalleri JMV, Pietschmann T, Wedemeyer H, Steinmann E, Todt D (2022): Intra-host analysis of hepaciviral glycoprotein evolution reveals signatures associated with viral persistence and clearance.
Virus Evol 8: veac007.
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Reinecke B, Frericks N, Lauber C, Dinkelborg K, Matthaei A, Vondran FWR, Behrendt P, Haid S, Brown RJP, Pietschmann T (2022): The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection.
J Virol 96: e01995-21.
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Pott F, Postmus D, Brown RJP, Wyler E, Neumann E, Landthaler M, Goffinet C (2021): Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Emerg Microbes Infect 10: 2151-2168.
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Qu B, Brown RJP (2021): Strategies to Inhibit Hepatitis B Virus at the Transcript Level.
Viruses 13: 1327.
Online-Abstract
Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP (2021): Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements.
J Virology 95: e00245-21.
Online-Abstract
Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GMGM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A (2021): Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2.
Stem Cell Res 56: 102535.
Online-Abstract
Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T (2020): Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Sci Adv 6: eabd3233.
Online-Abstract
Carpentier A, Sheldon J, Vondran FWR, Brown RJ, Pietschmann T (2020): Efficient Acute and Chronic Infection of Stem Cell-Derived Hepatocytes by Hepatitis C Virus.
Gut 69: 1659-1666.
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Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brueggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR, Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E (2020): C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.
J Hepatol 73: 549-558.
Online-Abstract
Kinast V, Leber SL, Brown RJP, Vieyres G, Behrendt P, Eßbach C, Strnad P, Vondran FWR, Cornberg M, Wex C, Pietschmann T, Haybaeck J, Todt D, Steinmann E (2019): Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver.
Cells 8: 610.
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Kleinert RDV, Montoya-Diaz E, Khera T, Welsch K, Tegtmeyer B, Hoehl S, Ciesek S, Brown RJP (2019): Yellow Fever: Integrating Current Knowledge with Technological Innovations to Identify Strategies for Controlling a Re-Emerging Virus.
Viruses 11: 960.
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